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Tbio
BIRC6
Baculoviral IAP repeat-containing protein 6

Protein Summary
Description
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000421745
  • ENSP00000393596
  • ENSG00000115760

Symbol
  • KIAA1289
  • BRUCE
  • APOLLON
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
transcription factor binding site profile
0.92
biological process
0.73
protein domain
0.73
cell line
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.09   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.09   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (166)
1 – 10 of 166
FSD2
Tbio
Novelty:  0.1302271
p_int:  0.998596806
p_ni:  0.001403194
Data Source:  BioPlex
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.997932835
p_ni:  0.002067165
Data Source:  BioPlex
AGRP
Tbio
Novelty:  0.00147804
p_int:  0.995231551
p_ni:  0.004768449
Score:  0.18
Data Source:  BioPlex,STRINGDB
NABP2
Tbio
Novelty:  0.09046897
p_int:  0.994255667
p_ni:  0.005744333
Data Source:  BioPlex
DIABLO
Tbio
Novelty:  0.0007851
p_int:  0.99347646
p_ni:  0.00652354
Score:  0.957
Data Source:  BioPlex,STRINGDB
ANGPTL3
Tclin
Novelty:  0.00595539
p_int:  0.993239067
p_ni:  0.006760933
Score:  0.188
Data Source:  BioPlex,STRINGDB
UGGT2
Tbio
Family:  Enzyme
Novelty:  0.20635638
p_int:  0.987090988
p_ni:  0.012909012
Score:  0.268
Data Source:  BioPlex,STRINGDB
PMCH
Tbio
Novelty:  0.00600873
p_int:  0.980432138
p_ni:  0.019567862
Data Source:  BioPlex
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.973675059
p_ni:  0.026324941
Data Source:  BioPlex
AKAP9
Tbio
Family:  Enzyme
Novelty:  0.0106532
p_int:  0.965482535
p_ni:  0.034517465
Score:  0.247
Data Source:  BioPlex,STRINGDB
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
2
2
2
95.1
testosterone measurement
1
3
3
89.7
1
3
3
86.6
red blood cell distribution width
2
1
2
77.6
smoking status measurement
2
1
2
71.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
2
95.1
testosterone measurement
3
89.7
3
86.6
red blood cell distribution width
2
77.6
smoking status measurement
2
71.2
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
baculoviral IAP repeat containing 6
VGNC:223
459138
Macaque
baculoviral IAP repeat containing 6
709443
Mouse
MGI:1276108
12211
Rat
RGD:1307247
313876
Dog
baculoviral IAP repeat containing 6
VGNC:38462
475718
Species
Name
OMA
EggNOG
Inparanoid
Chimp
baculoviral IAP repeat containing 6
Macaque
baculoviral IAP repeat containing 6
Mouse
Rat
Dog
baculoviral IAP repeat containing 6
Publication Statistics
PubMed Score 91.09
PubMed score by year
PubTator Score 66.01
PubTator score by year