Tbio UTP3 Something about silencing protein 10

Protein Summary

Description

Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity).

Uniprot Accession IDs

• Q9NQZ2
• Q6FI82

Gene Name

• UTP3

Ensembl ID

• ENST00000254803
• ENSP00000254803
• ENSG00000132467

Symbol

• CRLZ1
• SAS10
• CRL1
• CRLZ1
• SAS10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
disease perturbation	0.96
transcription factor binding site profile	0.94
histone modification site profile	0.89
virus perturbation	0.85

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Something About Silencing Protein 10

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Something About Silencing Protein 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.86   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 114   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.86   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (321)

Explore Interacting Targets

1 – 10 of 321

• See Interactions on String-DB

IMP3

Tbio

Novelty:  0.42681287

p_int:  0.999973723

p_ni:  0.000026277

Score:  0.999

Data Source:  BioPlex,STRINGDB

TF

Tbio

Novelty:  0.00231826

p_int:  0.99491222

p_ni:  0.00508778

Score:  0.177

Data Source:  BioPlex,STRINGDB

DIEXF

Tbio

Novelty:  0.05892659

p_int:  0.987388389

p_ni:  0.012611611

Score:  0.999

Data Source:  BioPlex,STRINGDB

RPS2

Tbio

Novelty:  0.00412313

p_int:  0.958579719

p_ni:  0.041420281

Score:  0.919

Data Source:  BioPlex,STRINGDB

NOP53

Tbio

Novelty:  0.00353077

p_int:  0.928363156

p_ni:  0.071636841

p_wrong:  4e-9

Score:  0.95

Data Source:  BioPlex,STRINGDB

DAXX

Tbio

Novelty:  0.00348585

p_int:  0.902341211

p_ni:  0.097658788

p_wrong:  1e-9

Data Source:  BioPlex

TUBA3C

Tchem

Novelty:  0.0187396

p_int:  0.890304792

p_ni:  0.109695208

Data Source:  BioPlex

PDGFB

Tbio

Novelty:  0.00080876

p_int:  0.874771218

p_ni:  0.125228782

Data Source:  BioPlex

ZNF2

Tbio

Family:  TF

Novelty:  0.01062543

p_int:  0.861537367

p_ni:  0.138462633

Data Source:  BioPlex

CDX1

Tbio

Family:  TF

Novelty:  0.00815821

p_int:  0.834539037

p_ni:  0.165460963

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (5)

Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Reactome	Metabolism of RNA	686 targets	R-HSA-8953854
Reactome	rRNA modification in the nucleus and cytosol	59 targets	R-HSA-6790901
Reactome	rRNA processing	217 targets	R-HSA-72312
Reactome	rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773

Name	Explore in Pharos	Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol	183 targets	R-HSA-6791226
Metabolism of RNA	686 targets	R-HSA-8953854
rRNA modification in the nucleus and cytosol	59 targets	R-HSA-6790901
rRNA processing	217 targets	R-HSA-72312
rRNA processing in the nucleus and cytosol	193 targets	R-HSA-8868773

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (1)

Components (4)

Processes (4)

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10

1 – 1 of 1

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body fat percentage	EFO_0007800	1	1	1		14.2
serum metabolite measurement	EFO_0005653	1	1	1		8.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body fat percentage	EFO_0007800	1		14.2
serum metabolite measurement	EFO_0005653	1		8.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Chromatin regulator
Citrullination
Complete proteome
Developmental protein
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
body fat percentage
serum metabolite measurement

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	UTP3, small subunit processome component		706536
Mouse	UTP3 small subunit processome component	MGI:1919230	65961
Rat	UTP3, small subunit processome component	RGD:1308540	305258
Dog	UTP3, small subunit processome component	VGNC:48213	475167
Horse	UTP3, small subunit processome component	VGNC:24864	100054342

Species	Name	OMA	EggNOG	Inparanoid
Macaque	UTP3, small subunit processome component
Mouse	UTP3 small subunit processome component
Rat	UTP3, small subunit processome component
Dog	UTP3, small subunit processome component
Horse	UTP3, small subunit processome component

Publication Statistics

PubMed Score 16.86

PubMed score by year

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PubTator Score 7.83

PubTator score by year

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Related Publications

Text Mined References (22)

GeneRif Annotations (2)

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10

0 of 0

PMID	Year	Title