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Tbio
ITM2C
Integral membrane protein 2C

Protein Summary
Description
Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326407
  • ENSP00000322100
  • ENSG00000135916
  • ENST00000326427
  • ENSP00000322730
  • ENST00000335005
  • ENSP00000335121

Symbol
  • BRI3
  • E25
  • BRI3
  • E25C
  • ITM3
  • BRICD2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor perturbation
0.88
disease perturbation
0.87
molecular function
0.84
small molecule perturbation
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.02   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.02   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
56.9
mean corpuscular volume
1
1
1
19.8
mean reticulocyte volume
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
56.9
mean corpuscular volume
1
19.8
mean reticulocyte volume
1
13.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integral membrane protein 2C
VGNC:1982
459998
Macaque
integral membrane protein 2C
711245
Mouse
MGI:1927594
64294
Rat
RGD:1309503
301575
Dog
integral membrane protein 2C
VGNC:42151
486156
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integral membrane protein 2C
Macaque
integral membrane protein 2C
Mouse
Rat
Dog
integral membrane protein 2C
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NQX7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (39)
1 – 10 of 39
MVB12B
Tbio
Novelty: 0.15964868
p_int: 0.999652298
p_ni: 0.000067051
p_wrong: 0.000280651
Score: 0.485
Data Source: BioPlex,STRINGDB
TTK
Tchem
Family: Kinase
Novelty: 0.00447957
Score: 0.743
Data Source: STRINGDB
KNDC1
Tdark
Novelty: 0.1459108
Score: 0.735
Data Source: STRINGDB
FCAMR
Tbio
Novelty: 0.05112165
Score: 0.725
Data Source: STRINGDB
RIT2
Tbio
Family: Enzyme
Novelty: 0.01672192
Score: 0.696
Data Source: STRINGDB
FCMR
Tbio
Novelty: 0.02321029
Score: 0.685
Data Source: STRINGDB
KIAA1755
Tdark
Novelty: 0.5138999
Score: 0.68
Data Source: STRINGDB
PCSK7
Tchem
Family: Enzyme
Novelty: 0.00307761
Score: 0.644
Data Source: STRINGDB
FURIN
Tchem
Family: Enzyme
Novelty: 0.00055079
Score: 0.633
Data Source: STRINGDB
SLC22A18
Tbio
Family: Transporter
Novelty: 0.0189809
Score: 0.622
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.02

PubMed score by year
PubTator Score  27.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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