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Tbio
ZNF331
Zinc finger protein 331

Protein Summary
Description
May be involved in transcriptional regulation. May play a role in spermatogenesis. This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. This gene may be methylated and silenced in cancer cells. This gene is located within a differentially methylated region (DMR) and shows allele-specific expression in placenta. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding the same protein. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253144
  • ENSP00000253144
  • ENSG00000130844
  • ENST00000411977
  • ENSP00000393336
  • ENST00000449416
  • ENSP00000393817
  • ENST00000504493
  • ENSP00000425517
  • ENST00000511154
  • ENSP00000421014
  • ENST00000511593
  • ENSP00000427439
  • ENST00000512387
  • ENSP00000421728
  • ENST00000513999
  • ENSP00000423156
  • ENST00000648122
  • ENSP00000496977
  • ENST00000648236
  • ENSP00000497263
  • ENST00000648397
  • ENSP00000497726
  • ENST00000648511
  • ENSP00000497652
  • ENST00000649326
  • ENSP00000498006

Symbol
  • RITA
  • ZNF361
  • ZNF463
  • RITA
  • ZNF361
  • ZNF463
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
transcription factor
0.64
cell type or tissue
0.58
protein domain
0.58
tissue sample
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.46   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.46   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Gene expression (Transcription) (R-HSA-74160)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Protein-Protein Interactions (97)
1 – 10 of 97
FAM172A
Tbio
Novelty: 0.1200899
p_int: 0.999998113
p_ni: 0.000001887
Data Source: BioPlex
FBXO38
Tbio
Novelty: 0.06588101
p_int: 0.999995663
p_ni: 0.000004337
Score: 0.173
Data Source: BioPlex,STRINGDB
CTNNBL1
Tbio
Novelty: 0.0189038
p_int: 0.999994241
p_ni: 0.000005759
Data Source: BioPlex
KIF7
Tbio
Novelty: 0.02734596
p_int: 0.999954335
p_ni: 0.000045664
Data Source: BioPlex
LRP4
Tbio
Novelty: 0.01336125
p_int: 0.999948238
p_ni: 0.000051762
Data Source: BioPlex
IPO8
Tbio
Novelty: 0.00934966
p_int: 0.999809407
p_ni: 0.000190593
Score: 0.432
Data Source: BioPlex,STRINGDB
TRIM39
Tbio
Family: Enzyme
Novelty: 0.0837441
p_int: 0.999789188
p_ni: 0.000210812
Score: 0.158
Data Source: BioPlex,STRINGDB
LRP1B
Tbio
Novelty: 0.01443405
p_int: 0.999728942
p_ni: 0.000271058
Data Source: BioPlex
NIN
Tbio
Novelty: 0.01312714
p_int: 0.99939045
p_ni: 0.000609538
p_wrong: 1.2e-8
Data Source: BioPlex
PPP2CA
Tchem
Family: Enzyme
Novelty: 0.00496839
p_int: 0.999383752
p_ni: 0.000616248
Score: 0.169
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  19.46

PubMed score by year
PubTator Score  25.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer