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Tbio
NPDC1
Neural proliferation differentiation and control protein 1

Protein Summary
Description
Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371601
  • ENSP00000360660
  • ENSG00000107281

Symbol
  • CAB
  • CAB-
  • CAB1
  • CAB-1
  • NPDC-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
virus perturbation
0.88
kinase perturbation
0.71
transcription factor binding site profile
0.68
tissue
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.39   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.39   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
4
91.5
monocyte percentage of leukocytes
2
2
2
88
leukocyte count
2
2
3
70.2
central corneal thickness
3
2
0
2.9
69.8
lymphocyte percentage of leukocytes
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
91.5
monocyte percentage of leukocytes
2
88
leukocyte count
3
70.2
central corneal thickness
0
2.9
69.8
lymphocyte percentage of leukocytes
1
49.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neural proliferation, differentiation and control 1
VGNC:14472
464882
Macaque
neural proliferation, differentiation and control 1
707453
Mouse
MGI:1099802
18146
Rat
RGD:1303156
296562
Dog
neural proliferation, differentiation and control 1
VGNC:43915
480668
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neural proliferation, differentiation and control 1
Macaque
neural proliferation, differentiation and control 1
Mouse
Rat
Dog
neural proliferation, differentiation and control 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NQX5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (39)
1 – 10 of 39
ATP11A
Tbio
Family:  Transporter
Novelty:  0.05334905
p_int:  0.999999998
p_ni:  2e-9
Score:  0.403
Data Source:  BioPlex,STRINGDB
PTER
Tbio
Family:  Enzyme
Novelty:  0.01347498
p_int:  0.999890493
p_ni:  0.000109483
p_wrong:  2.4e-8
Score:  0.243
Data Source:  BioPlex,STRINGDB
TBC1D23
Tbio
Novelty:  0.18566729
p_int:  0.999208602
p_ni:  0.000782419
p_wrong:  0.000008979
Score:  0.214
Data Source:  BioPlex,STRINGDB
TCAF2
Tbio
Family:  Enzyme
Novelty:  0.37070492
p_int:  0.999027792
p_ni:  0.000963959
p_wrong:  0.000008249
Score:  0.211
Data Source:  BioPlex,STRINGDB
YJU2
Tdark
Novelty:  0.75647391
p_int:  0.996443871
p_ni:  0.003555883
p_wrong:  2.47e-7
Score:  0.181
Data Source:  BioPlex,STRINGDB
SNX17
Tbio
Novelty:  0.03960737
p_int:  0.986022022
p_ni:  0.013977978
Score:  0.201
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.976748361
p_ni:  0.023246213
p_wrong:  0.000005426
Score:  0.28
Data Source:  BioPlex,STRINGDB
PILRA
Tbio
Novelty:  0.05154386
Score:  0.9
Data Source:  Reactome,STRINGDB
FUT7
Tchem
Family:  Enzyme
Novelty:  0.01257357
Score:  0.745
Data Source:  STRINGDB
AGFG1
Tbio
Novelty:  0.00121561
Score:  0.71
Data Source:  STRINGDB
Publication Statistics
PubMed Score  45.39

PubMed score by year
PubTator Score  625.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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