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Tbio
MYO5C
Unconventional myosin-Vc

Protein Summary
Description
May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261839
  • ENSP00000261839
  • ENSG00000128833
  • ENST00000559459
  • ENSP00000454064
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
virus perturbation
0.92
disease perturbation
0.9
PubMedID
0.76
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.49   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.49   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
2
1.1
89.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
89.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin VC
VGNC:14645
453441
Macaque
myosin VC
695333
Mouse
MGI:2442485
208943
Rat
RGD:1309994
315820
Dog
myosin VC
VGNC:43570
487555
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin VC
Macaque
myosin VC
Mouse
Rat
Dog
myosin VC
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NQX4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (123)
1 – 10 of 123
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.999987209
p_ni: 0.000012791
Score: 0.238
Data Source: BioPlex,STRINGDB
MOAP1
Tbio
Novelty: 0.05070263
p_int: 0.999878842
p_ni: 0.000121158
Score: 0.173
Data Source: BioPlex,STRINGDB
PPP6R2
Tbio
Family: Enzyme
Novelty: 0.12886225
p_int: 0.999854043
p_ni: 0.000145957
Data Source: BioPlex
DKK3
Tbio
Novelty: 0.00519275
p_int: 0.999848326
p_ni: 0.000151674
Score: 0.165
Data Source: BioPlex,STRINGDB
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.997625813
p_ni: 0.002374187
Data Source: BioPlex
DTNBP1
Tbio
Novelty: 0.00341619
p_int: 0.997132205
p_ni: 0.002867795
Score: 0.171
Data Source: BioPlex,STRINGDB
GMNN
Tbio
Novelty: 0.00436572
p_int: 0.99530193
p_ni: 0.00469807
Data Source: BioPlex
TMOD1
Tbio
Novelty: 0.01142927
p_int: 0.994039484
p_ni: 0.005960516
Score: 0.489
Data Source: BioPlex,STRINGDB
SPDEF
Tbio
Family: TF
Novelty: 0.00618802
p_int: 0.993300155
p_ni: 0.006699845
Score: 0.282
Data Source: BioPlex,STRINGDB
EIF2B5
Tbio
Novelty: 0.0102209
p_int: 0.992439446
p_ni: 0.007560554
Data Source: BioPlex
Publication Statistics
PubMed Score  17.49

PubMed score by year
PubTator Score  10.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer