Protein Summary
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently know ...more
- ENST00000315266
- ENSP00000312771
- ENSG00000171723
- ENST00000478722
- ENSP00000417901
- GPH
- KIAA1385
- GPH
- GEPH
- HKPX1
- GPHRYN
- MOCODC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.93 | ||
transcription factor binding site profile | 0.91 | ||
transcription factor perturbation | 0.8 | ||
kinase perturbation | 0.76 | ||
virus perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 533.88 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 343 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 533.88 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 343 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (150)
TSSK1B
Family: Kinase
Novelty: 0.01931035
p_int: 0.999925548
p_ni: 0.000074452
Score: 0.295
Data Source: BioPlex,STRINGDB
ODF3L2
Novelty: 1.4355239
p_int: 0.999879633
p_ni: 0.000120367
Score: 0.534
Data Source: BioPlex,STRINGDB
PRPF4
Novelty: 0.08229072
p_int: 0.999713076
p_ni: 0.000286924
Score: 0.215
Data Source: BioPlex,STRINGDB
KLKB1
Family: Enzyme
Novelty: 0.00109438
p_int: 0.999519389
p_ni: 0.000480612
Score: 0.332
Data Source: BioPlex,STRINGDB
KMO
Family: Enzyme
Novelty: 0.01469543
p_int: 0.945680889
p_ni: 0.054319111
Score: 0.454
Data Source: BioPlex,STRINGDB
STS
Family: Enzyme
Novelty: 0.00324549
p_int: 0.777776758
p_ni: 0.222223242
Score: 0.173
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (16)
Upstream (16)
1 – 5 of 16
Pathways (13)
Reactome (4)
KEGG (3)
PathwayCommons (1)
UniProt (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Reactome | Molybdenum cofactor biosynthesis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Molybdenum cofactor biosynthesis | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (6)
Components (10)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 81.2 | |||||
reticulocyte measurement | 1 | 1 | 1 | 10.7 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 1 | 81.2 | |||||
reticulocyte measurement | 1 | 10.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | gephyrin | VGNC:3413 | 452976 | |||||
Macaque | gephyrin | 709677 | ||||||
Mouse | MGI:109602 | 268566 | ||||||
Rat | RGD:69194 | 64845 | ||||||
Dog | gephyrin | VGNC:41380 | 490739 | |||||
Publication Statistics
PubMed Score 533.88
PubMed score by year
PubTator Score 222.57
PubTator score by year
Related Publications
Text Mined References (58)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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