You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PRDM6
Putative histone-lysine N-methyltransferase PRDM6

Protein Summary
Description
Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression. The protein encoded by this gene is a transcriptional repressor and a member of the PRDM family. Family members contain a PR d ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407847
  • ENSP00000384725
  • ENSG00000061455

Symbol
  • PFM3
  • PDA3
  • KMT8C
  • PRISM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
biological process
0.73
PubMedID
0.62
tissue
0.62
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.78   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.78   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (30)
1 – 10 of 30
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.999999255
p_ni:  6.35e-7
p_wrong:  1.1e-7
Score:  0.163
Data Source:  BioPlex,STRINGDB
CBFA2T2
Tbio
Novelty:  0.06262074
p_int:  0.999997993
p_ni:  1e-8
p_wrong:  0.000001997
Score:  0.953
Data Source:  BioPlex,STRINGDB
PRDM14
Tbio
Family:  TF; Epigenetic
Novelty:  0.01776592
p_int:  0.999993971
p_ni:  6.16e-7
p_wrong:  0.000005413
Score:  0.854
Data Source:  BioPlex,STRINGDB
PRDM8
Tbio
Family:  TF; Epigenetic
Novelty:  0.08003201
Score:  0.785
Data Source:  STRINGDB
IBSP
Tbio
Novelty:  0.00092598
Score:  0.656
Data Source:  STRINGDB
CAMKMT
Tbio
Family:  Enzyme
Novelty:  0.00382649
Score:  0.651
Data Source:  STRINGDB
PLOD2
Tbio
Family:  Enzyme
Novelty:  0.00403916
Score:  0.65
Data Source:  STRINGDB
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
Score:  0.65
Data Source:  STRINGDB
PLOD3
Tbio
Family:  Enzyme
Novelty:  0.02211629
Score:  0.65
Data Source:  STRINGDB
TMEM184B
Tdark
Novelty:  0.35340207
Score:  0.644
Data Source:  STRINGDB
Gene Ontology Terms (11)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
1
2
2
87.2
electrocardiography
1
1
11
60.5
1
1
1
46.9
Calcium channel blocker use measurement
1
1
1
44.2
heart rate response to recovery post exercise
2
1
2
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
balding measurement
2
87.2
electrocardiography
11
60.5
1
46.9
Calcium channel blocker use measurement
1
44.2
heart rate response to recovery post exercise
2
42.3
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 6
VGNC:13567
742318
Mouse
MGI:2684938
225518
Rat
RGD:1559594
307305
Dog
PR/SET domain 6
VGNC:44950
100687856
Horse
PR/SET domain 6
VGNC:21817
100073092
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 6
Mouse
Rat
Dog
PR/SET domain 6
Horse
PR/SET domain 6
Publication Statistics
PubMed Score 26.78
PubMed score by year
PubTator Score 73.73
PubTator score by year