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Tchem
CNGB3
Cyclic nucleotide-gated cation channel beta-3

Protein Summary
Description
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also k ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320005
  • ENSP00000316605
  • ENSG00000170289

Symbol
  • ACHM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
gene perturbation
0.82
cell type or tissue
0.7
cell line
0.64
virus perturbation
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.3   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.3   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
71.1
cognitive function measurement
1
1
1
43.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
71.1
cognitive function measurement
1
43.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclic nucleotide gated channel beta 3
VGNC:910
464272
Macaque
cyclic nucleotide gated channel beta 3
694758
Mouse
MGI:1353562
30952
Rat
RGD:1565364
500418
Dog
cyclic nucleotide gated channel beta 3
VGNC:39398
403554
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclic nucleotide gated channel beta 3
Macaque
cyclic nucleotide gated channel beta 3
Mouse
Rat
Dog
cyclic nucleotide gated channel beta 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NQW8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (100)
1 – 10 of 100
GNAT2
Tbio
Novelty: 0.01683655
Score: 0.997
Data Source: STRINGDB
PDE6C
Tclin
Family: Enzyme
Novelty: 0.02239368
Score: 0.995
Data Source: STRINGDB
PDE6H
Tclin
Family: Enzyme
Novelty: 0.0524804
Score: 0.982
Data Source: STRINGDB
CNGA3
Tchem
Family: IC
Novelty: 0.00818181
Score: 0.967
Data Source: STRINGDB
PDE6A
Tclin
Family: Enzyme
Novelty: 0.02680494
Score: 0.925
Data Source: STRINGDB
GUCY2D
Tbio
Family: Kinase
Novelty: 0.00578343
Score: 0.9
Data Source: STRINGDB
PDE6B
Tclin
Family: Enzyme
Novelty: 0.001105
Score: 0.836
Data Source: STRINGDB
GNAT1
Tbio
Novelty: 0.03042002
Score: 0.818
Data Source: STRINGDB
GUCY2F
Tbio
Family: Kinase
Novelty: 0.03634576
Score: 0.813
Data Source: STRINGDB
CNGA1
Tchem
Family: IC
Novelty: 0.00848214
Score: 0.794
Data Source: STRINGDB
Publication Statistics
PubMed Score  84.30

PubMed score by year
PubTator Score  54.15

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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