Tchem CNGB3 Cyclic nucleotide-gated cation channel beta-3

Protein Summary

Description

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• Q9NQW8
• C9JA51
• Q9NRE9

Gene Name

• CNGB3

Ensembl ID

• ENST00000320005
• ENSP00000316605
• ENSG00000170289

Symbol

• ACHM1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
gene perturbation	0.82
cell type or tissue	0.7
cell line	0.64
virus perturbation	0.64

Protein Classes

DTO Classes

Protein / Ion Channel / Cyclic Nucleotide-gated Cation Channel Family / Cngb3 Subfamily / Cyclic Nucleotide-gated Cation Channel Beta-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.65   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.65   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0