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Tbio
ANLN
Anillin

Protein Summary
Description
Required for cytokinesis (PubMed:16040610). Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis (PubMed:23870127). May play a significant role in podocyte cell migration (PubMed:24676636). This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265748
  • ENSP00000265748
  • ENSG00000011426
  • ENST00000396068
  • ENSP00000379380

Symbol
  • scra
  • FSGS8
  • Scraps
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
transcription factor binding site profile
0.92
transcription factor perturbation
0.91
PubMedID
0.84
small molecule perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.59   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.59   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
75.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
75.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
anillin actin binding protein
VGNC:4262
463351
Macaque
anillin actin binding protein
706404
Mouse
MGI:1920174
68743
Rat
Dog
anillin actin binding protein
VGNC:37922
482401
Species
Name
OMA
EggNOG
Inparanoid
Chimp
anillin actin binding protein
Macaque
anillin actin binding protein
Mouse
Rat
Dog
anillin actin binding protein
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NQW6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (26)
Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Retinoblastoma Gene in Cancer
WikiPathways
Retinoblastoma Gene in Cancer
WikiPathways
Retinoblastoma Gene in Cancer
WikiPathways
Retinoblastoma Gene in Cancer
WikiPathways
Retinoblastoma Gene in Cancer
Name
Explore in Pharos
Explore in Source
Retinoblastoma Gene in Cancer
Retinoblastoma Gene in Cancer
Retinoblastoma Gene in Cancer
Retinoblastoma Gene in Cancer
Retinoblastoma Gene in Cancer
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (199)
1 – 10 of 199
IQGAP3
Tbio
Family: Enzyme
Novelty: 0.05874747
p_int: 0.999999776
p_ni: 2.23e-7
p_wrong: 1e-9
Score: 0.383
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.858514937
p_ni: 0.003483645
p_wrong: 0.138001418
Data Source: BioPlex
KIF23
Tbio
Novelty: 0.00719651
Score: 0.988
Data Source: STRINGDB
RACGAP1
Tbio
Family: Enzyme
Novelty: 0.01197099
Score: 0.985
Data Source: STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.982
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.981
Data Source: STRINGDB
KIF11
Tchem
Novelty: 0.00170673
Score: 0.955
Data Source: STRINGDB
KIF20A
Tchem
Novelty: 0.01640924
Score: 0.943
Data Source: STRINGDB
BUB1
Tchem
Family: Kinase
Novelty: 0.00327514
Score: 0.939
Data Source: STRINGDB
ECT2
Tbio
Novelty: 0.00834186
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  211.59

PubMed score by year
PubTator Score  35.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer