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Tdark
SEC31B
Protein transport protein Sec31B

Protein Summary
Description
As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum. This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II phosphorylation site. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370345
  • ENSP00000359370
  • ENSG00000075826
  • ENST00000462434
  • ENSP00000474124

Symbol
  • SEC31L2
  • SEC31L2
  • SEC31B-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
cellular component
0.71
tissue
0.59
cell type or tissue
0.58
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.49   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.49   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
palmitoleic acid measurement
1
1
1
45.7
fatty acid measurement
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
palmitoleic acid measurement
1
45.7
fatty acid measurement
1
28.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC31 homolog B, COPII coat complex component
VGNC:5720
100610792
Macaque
SEC31 homolog B, COPII coat complex component
710333
Mouse
MGI:2685187
240667
Rat
RGD:1598329
309433
Dog
SEC31 homolog B, COPII coat complex component
VGNC:45977
486842
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC31 homolog B, COPII coat complex component
Macaque
SEC31 homolog B, COPII coat complex component
Mouse
Rat
Dog
SEC31 homolog B, COPII coat complex component
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NQW1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Protein processing in endoplasmic reticulum
Name
Explore in Pharos
Explore in Source
Protein processing in endoplasmic reticulum
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (114)
1 – 10 of 114
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.975144664
p_ni:  0.024855336
Score:  0.675
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.974006542
p_ni:  0.025993458
Score:  0.265
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.962827208
p_ni:  0.037172792
Score:  0.204
Data Source:  BioPlex,STRINGDB
CCT6A
Tbio
Novelty:  0.02368046
p_int:  0.905376335
p_ni:  0.094623665
Score:  0.505
Data Source:  BioPlex,STRINGDB
TCP1
Tbio
Novelty:  0.00395241
p_int:  0.838520685
p_ni:  0.161479315
Score:  0.357
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.822788258
p_ni:  0.177211742
Score:  0.636
Data Source:  BioPlex,STRINGDB
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.768772216
p_ni:  0.231227784
Score:  0.64
Data Source:  BioPlex,STRINGDB
CCT4
Tbio
Novelty:  0.01176123
p_int:  0.75583167
p_ni:  0.24416833
Score:  0.563
Data Source:  BioPlex,STRINGDB
SEC13
Tbio
Novelty:  0.00709413
Score:  0.999
Data Source:  STRINGDB
SEC23A
Tbio
Novelty:  0.0384262
Score:  0.991
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.49

PubMed score by year
PubTator Score  0.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer