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Tbio
PRDM8
PR domain zinc finger protein 8

Protein Summary
Description
Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3 (By similarity). Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR (By similarity). Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation (By similarity). In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival (By similarity). This gene encodes a protein that belongs to a conserved family of histone methyltransferases that predominantly act as negative regulators of transcription. The encoded protein contains an N-terminal Su(var)3-9, Enhancer-of-zeste, and Trithorax (SET) domain and a double zinc-finger domain. Knockout of this gene in mouse results in mistargeting by neurons of the dorsal telencephalon, abnormal itch-like behavior, and impaired differentiation of rod bipolar cells. In humans, the protein has ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339711
  • ENSP00000339764
  • ENSG00000152784
  • ENST00000415738
  • ENSP00000406998
  • ENST00000504452
  • ENSP00000423985

Symbol
  • PFM5
  • PFM5
  • EPM10
  • KMT8D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
transcription factor
0.8
biological process
0.75
PubMedID
0.62
tissue sample
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.18   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.18   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (25)
1 – 10 of 25
PRDM6
Tbio
Family:  TF; Epigenetic
Novelty:  0.04172889
Score:  0.785
Data Source:  STRINGDB
BHLHE22
Tbio
Family:  TF
Novelty:  0.00442982
Score:  0.779
Data Source:  STRINGDB
EPM2A
Tbio
Family:  Enzyme
Novelty:  0.00846992
Score:  0.767
Data Source:  STRINGDB
EPM2A
Tbio
Novelty:  0.00846992
Score:  0.767
Data Source:  STRINGDB
NHLRC1
Tbio
Family:  Enzyme
Novelty:  0.00927388
Score:  0.717
Data Source:  STRINGDB
PRDM2
Tbio
Family:  TF; Epigenetic
Novelty:  0.00556321
Score:  0.706
Data Source:  STRINGDB
PRDM15
Tbio
Family:  TF; Epigenetic
Novelty:  0.17392284
Score:  0.69
Data Source:  STRINGDB
EBF4
Tbio
Family:  TF
Novelty:  0.13329471
Score:  0.658
Data Source:  STRINGDB
PRDM5
Tbio
Family:  TF; Epigenetic
Novelty:  0.01689997
Score:  0.595
Data Source:  STRINGDB
BTBD3
Tbio
Novelty:  0.16338626
Score:  0.55
Data Source:  STRINGDB
Gene Ontology Terms (6)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
9
8
20
96.8
balding measurement
2
3
3
95.9
2
7
8
94.9
glomerular filtration rate
6
3
6
7.4
91.6
hematocrit
3
3
3
90.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
20
96.8
balding measurement
3
95.9
8
94.9
glomerular filtration rate
6
7.4
91.6
hematocrit
3
90.7
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
PR/SET domain 8
696013
Mouse
MGI:1924880
77630
Rat
RGD:1311628
305198
Dog
PR/SET domain 8 [Source:HGNC Symbol;Acc:HGNC:13993]
Opossum
PR/SET domain 8 [Source:HGNC Symbol;Acc:HGNC:13993]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
PR/SET domain 8
Mouse
Rat
Dog
PR/SET domain 8 [Source:HGNC Symbol;Acc:HGNC:13993]
Opossum
PR/SET domain 8 [Source:HGNC Symbol;Acc:HGNC:13993]
Publication Statistics
PubMed Score 14.18
PubMed score by year
PubTator Score 5.02
PubTator score by year