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Tbio
PRDM10
PR domain zinc finger protein 10

Protein Summary
Description
May be involved in transcriptional regulation. The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304538
  • ENSP00000302669
  • ENSG00000170325
  • ENST00000358825
  • ENSP00000351686
  • ENST00000360871
  • ENSP00000354118
  • ENST00000423662
  • ENSP00000398431
  • ENST00000526082
  • ENSP00000432237

Symbol
  • KIAA1231
  • PFM7
  • TRIS
  • PFM7
  • TRIS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
transcription factor
0.78
microRNA
0.74
protein domain
0.73
transcription factor binding site profile
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.11   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.11   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HIV-1 infection
1
1
1
63.3
viral load
1
1
1
63.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HIV-1 infection
1
63.3
viral load
1
63.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 10
VGNC:53161
451664
Macaque
PR/SET domain 10
715177
Mouse
MGI:2682952
382066
Rat
RGD:1560384
500964
Dog
PR/SET domain 10
VGNC:44945
489279
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PR/SET domain 10
Macaque
PR/SET domain 10
Mouse
Rat
Dog
PR/SET domain 10
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NQV6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (142)
1 – 10 of 142
SDC2
Tbio
Novelty: 0.00597758
p_int: 0.999985181
p_ni: 0.000014819
Data Source: BioPlex
PRICKLE3
Tbio
Novelty: 0.26347141
p_int: 0.999961186
p_ni: 0.000038812
p_wrong: 3e-9
Data Source: BioPlex
CD44
Tbio
Novelty: 0.00011321
p_int: 0.999911867
p_ni: 0.000088133
Score: 0.367
Data Source: BioPlex,STRINGDB
CASQ2
Tbio
Novelty: 0.00775794
p_int: 0.999848645
p_ni: 0.000151355
Data Source: BioPlex
SDC1
Tbio
Novelty: 0.00044792
p_int: 0.99975567
p_ni: 0.000244327
p_wrong: 3e-9
Score: 0.299
Data Source: BioPlex,STRINGDB
RAP1GDS1
Tbio
Family: Enzyme
Novelty: 0.06140479
p_int: 0.99941094
p_ni: 0.00058906
Data Source: BioPlex
IL7R
Tbio
Novelty: 0.00107223
p_int: 0.999387215
p_ni: 0.000612784
p_wrong: 1e-9
Data Source: BioPlex
BHLHA15
Tbio
Family: TF
Novelty: 0.02721846
p_int: 0.996596738
p_ni: 0.003403262
Data Source: BioPlex
GPC3
Tbio
Novelty: 0.00151823
p_int: 0.995340315
p_ni: 0.004659669
p_wrong: 1.6e-8
Data Source: BioPlex
PDCD2
Tbio
Novelty: 0.05054811
p_int: 0.991442766
p_ni: 0.00855721
p_wrong: 2.5e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  30.11

PubMed score by year
PubTator Score  3.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer