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Tchem
PAK6
Serine/threonine-protein kinase PAK 6

Protein Summary
Description
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. This gene represents readthrough transcription between the genes BUB1B (mitotic checkpoint serine/threonine-protein kinase BUB1 beta) and PAK6 (serine/threonine-protein kinase PAK 6). The protein encoded by the readthrough transcripts is the same as the product of the downstream gene (PAK6). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260404
  • ENSP00000260404
  • ENSG00000137843
  • ENST00000455577
  • ENSP00000409465
  • ENST00000542403
  • ENSP00000439597
  • ENST00000560346
  • ENSP00000453858

Symbol
  • PAK5
  • PAK5
  • PAK6
  • PAK-5
  • PAK-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
hub protein
0.79
protein domain
0.73
transcription factor
0.7
cell type or tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.02   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 494   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.02   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 494   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (59)
PAK4
Tchem
Family:  Kinase
Novelty:  0.0068821
p_int:  0.999997283
p_ni:  1.7e-8
p_wrong:  0.000002701
Data Source:  BioPlex
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.960830957
p_ni:  0.039169043
Score:  0.552
Data Source:  BioPlex,STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.921006719
p_ni:  0.078993281
Score:  0.195
Data Source:  BioPlex,STRINGDB
YWHAE
Tbio
Novelty:  0.00431876
p_int:  0.769658186
p_ni:  0.230341814
Score:  0.172
Data Source:  BioPlex,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.997
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.922
Data Source:  STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.916
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.91
Data Source:  STRINGDB
NCK1
Tbio
Novelty:  0.00352084
Score:  0.875
Data Source:  STRINGDB
RAF1
Tclin
Family:  Kinase
Novelty:  0.00117121
Score:  0.866
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (32)
Activation of RAC1 (R-HSA-428540)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAC1
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Activation of RAC1
Axon guidance
Developmental Biology
Signaling by ROBO receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
4
2
1.1
89.1
1
1
0
33.3
79.5
1
1
0
100
77.3
waist-hip ratio
1
1
1
46.1
leukocyte count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
89.1
0
33.3
79.5
0
100
77.3
waist-hip ratio
1
46.1
leukocyte count
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
p21 (RAC1) activated kinase 6
701589
Mouse
MGI:2679420
214230
Rat
RGD:1306213
296078
Dog
p21 (RAC1) activated kinase 6
100856038
Horse
p21 (RAC1) activated kinase 6
100071463
Species
Name
OMA
EggNOG
Inparanoid
Macaque
p21 (RAC1) activated kinase 6
Mouse
Rat
Dog
p21 (RAC1) activated kinase 6
Horse
p21 (RAC1) activated kinase 6
Publication Statistics
PubMed Score 43.02
PubMed score by year
Patents
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Related Publications
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0 of 0
PMID
Year
Title