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Tbio
EXOSC3
Exosome complex component RRP40

Protein Summary
Description
Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327304
  • ENSP00000323046
  • ENSG00000107371
  • ENST00000396521
  • ENSP00000379775
  • ENST00000465229
  • ENSP00000418422

Symbol
  • RRP40
  • p10
  • PCH1B
  • RRP40
  • Rrp40p
  • CGI-102
  • hRrp-40
  • bA3J10.7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
interacting protein
0.87
transcription factor binding site profile
0.81
cellular component
0.76
histone modification site profile
0.75


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.39   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.39   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exosome component 3
VGNC:4687
465105
Macaque
exosome component 3
716347
Mouse
MGI:1913612
66362
Rat
RGD:1304739
313243
Dog
exosome component 3
VGNC:40524
481616
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exosome component 3
Macaque
exosome component 3
Mouse
Rat
Dog
exosome component 3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NQT5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
KSRP (KHSRP) binds and destabilizes mRNA
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Deadenylation-dependent mRNA decay
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Gene Ontology Terms (25)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (222)
1 – 10 of 222
C1D
Tbio
Novelty: 0.00997109
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC1
Tbio
Novelty: 0.01386842
p_int: 0.999999941
p_ni: 5.9e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
DIS3L
Tdark
Family: Enzyme
Novelty: 0.12886408
p_int: 0.999999795
p_ni: 2.05e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC7
Tbio
Family: Enzyme
Novelty: 0.07422851
p_int: 0.999999733
p_ni: 2.67e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC8
Tbio
Family: Enzyme
Novelty: 0.02013403
p_int: 0.999998193
p_ni: 0.000001807
Score: 0.999
Data Source: BioPlex,STRINGDB
EXOSC10
Tbio
Novelty: 0.00335571
p_int: 0.99999136
p_ni: 0.00000864
Score: 0.999
Data Source: BioPlex,STRINGDB
HBS1L
Tbio
Novelty: 0.00125579
p_int: 0.999987314
p_ni: 0.000012686
Score: 0.997
Data Source: BioPlex,STRINGDB
MPHOSPH6
Tbio
Family: Enzyme
Novelty: 0.24387167
p_int: 0.999970761
p_ni: 0.00002924
Score: 0.999
Data Source: BioPlex,STRINGDB
RBM7
Tbio
Novelty: 0.07482689
p_int: 0.999782582
p_ni: 0.000217418
Score: 0.923
Data Source: BioPlex,STRINGDB
EXOSC5
Tbio
Family: Enzyme
Novelty: 0.03352493
p_int: 0.999147326
p_ni: 0.000852674
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  36.39

PubMed score by year
PubTator Score  23.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer