Tbio EXOSC3 Exosome complex component RRP40

Protein Summary

Description

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC3 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC9 and EXOSC5. This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• Q9NQT5
• A8K0K6
• Q5QP85
• Q9Y3A8

Gene Name

• EXOSC3

Ensembl ID

• ENST00000327304
• ENSP00000323046
• ENSG00000107371
• ENST00000396521
• ENSP00000379775
• ENST00000465229
• ENSP00000418422

Symbol

• RRP40
• p10
• PCH1B
• RRP40
• Rrp40p
• CGI-102
• hRrp-40
• bA3J10.7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.94
interacting protein	0.87
transcription factor binding site profile	0.81
cellular component	0.76
histone modification site profile	0.75

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Exoribonuclease / Exosome Complex Component Rrp40

Protein / Nucleic Acid Binding / Rna Binding Protein / Exoribonuclease / Exosome Complex Component Rrp40

Protein / Hydrolase / Esterase / Exosome Complex Component Rrp40

DTO Classes

Protein / Enzyme / Nuclease / Exoribonuclease / Exosome Complex Component Rrp40

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.07   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 262   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.07   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0