Tchem GPR84 G-protein coupled receptor 84

Protein Summary

Description

Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.

Uniprot Accession IDs

• Q9NQS5
• B6V9G7

Gene Name

• GPR84

Ensembl ID

• ENST00000267015
• ENSP00000267015
• ENSG00000139572
• ENST00000551809
• ENSP00000450310

Symbol

• EX33
• EX33
• GPCR4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.65
tissue sample	0.62
gene perturbation	0.59
cell line	0.53
transcription factor	0.53

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / G-protein Coupled Receptor 84

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Galanin Like / G-protein Coupled Receptor 84

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.36   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 283   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.36   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 373

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0