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Tchem
GPR84
G-protein coupled receptor 84

Protein Summary
Description
Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267015
  • ENSP00000267015
  • ENSG00000139572
  • ENST00000551809
  • ENSP00000450310

Symbol
  • EX33
  • EX33
  • GPCR4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
tissue sample
0.62
gene perturbation
0.59
cell line
0.53
transcription factor
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.41   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.41   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 365
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
Genetic Construct
GPR84-Tango
image for GPR84-Tango
Details:
  • Vector:  addgene66377
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPR84-Tango
Order Genetic Construct from:
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
6
9
99.5
platelet count
5
4
5
8.7
97.9
red blood cell distribution width
4
2
6
95.6
mean corpuscular volume
1
2
2
94.4
reticulocyte measurement
2
2
2
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
99.5
platelet count
5
8.7
97.9
red blood cell distribution width
6
95.6
mean corpuscular volume
2
94.4
reticulocyte measurement
2
88
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 84
VGNC:8600
467012
Macaque
G protein-coupled receptor 84
705309
Mouse
MGI:1934129
80910
Rat
RGD:1585277
688730
Dog
G protein-coupled receptor 84
VGNC:41446
100687941
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 84
Macaque
G protein-coupled receptor 84
Mouse
Rat
Dog
G protein-coupled receptor 84
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NQS5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Immune System
Innate Immune System
Neutrophil degranulation
Protein-Protein Interactions (285)
1 – 10 of 285
CERS6
Tbio
Family:  TF
Novelty:  0.01956925
p_int:  0.800095668
p_ni:  0.198743561
p_wrong:  0.001160771
Score:  0.416
Data Source:  BioPlex,STRINGDB
CLEC5A
Tbio
Novelty:  0.01710591
Score:  0.953
Data Source:  STRINGDB
MCEMP1
Tdark
Novelty:  0.14180782
Score:  0.944
Data Source:  STRINGDB
GPR39
Tchem
Family:  GPCR
Novelty:  0.01244607
Score:  0.943
Data Source:  STRINGDB
CD36
Tbio
Novelty:  0.00140825
Score:  0.939
Data Source:  STRINGDB
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
Score:  0.937
Data Source:  STRINGDB
ITGAM
Tbio
Novelty:  0.00017521
Score:  0.935
Data Source:  STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
Score:  0.93
Data Source:  STRINGDB
LILRB2
Tbio
Novelty:  0.00545569
Score:  0.93
Data Source:  STRINGDB
GPBAR1
Tchem
Family:  GPCR
Novelty:  0.00290465
Score:  0.929
Data Source:  STRINGDB
Publication Statistics
PubMed Score  57.41

PubMed score by year
PubTator Score  16.77

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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