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Tchem
GPR84
G-protein coupled receptor 84

Protein Summary
Description
Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267015
  • ENSP00000267015
  • ENSG00000139572
  • ENST00000551809
  • ENSP00000450310

Symbol
  • EX33
  • EX33
  • GPCR4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
tissue sample
0.62
gene perturbation
0.59
cell line
0.53
transcription factor
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.36   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.36   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 373
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0