You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NECTIN3
Nectin-3

Protein Summary
Description
Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319792
  • ENSP00000321514
  • ENSG00000177707
  • ENST00000485303
  • ENSP00000418070
  • ENST00000493615
  • ENSP00000420579

Symbol
  • PRR3
  • PVRL3
  • PPR3
  • PRR3
  • CD113
  • PVRL3
  • PVRR3
  • CDW113
  • NECTIN-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.19   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.19   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Nectin/Necl trans heterodimerization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Nectin/Necl trans heterodimerization
Protein-Protein Interactions (60)
1 – 10 of 60
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.999954501
p_ni: 0.000020557
p_wrong: 0.000024943
Data Source: BioPlex
NECTIN1
Tbio
Novelty: 0.00348549
p_int: 0.99983781
p_ni: 3e-9
p_wrong: 0.000162186
Score: 0.985
Data Source: BioPlex,Reactome,STRINGDB
NPTX1
Tbio
Novelty: 0.02872516
p_int: 0.999802626
p_ni: 0.000197374
Score: 0.154
Data Source: BioPlex,STRINGDB
HFE
Tbio
Novelty: 0.00042077
p_int: 0.998961812
p_ni: 0.001013807
p_wrong: 0.000024381
Data Source: BioPlex
MAK
Tchem
Family: Kinase
Novelty: 0.04630863
p_int: 0.997773794
p_ni: 2.61e-7
p_wrong: 0.002225944
Score: 0.527
Data Source: BioPlex,STRINGDB
NECTIN2
Tbio
Novelty: 0.00910836
p_int: 0.99437014
p_ni: 0.00562986
Score: 0.969
Data Source: BioPlex,Reactome,STRINGDB
ASPH
Tbio
Family: Enzyme
Novelty: 0.00291455
p_int: 0.962793815
p_ni: 0.037206185
Score: 0.194
Data Source: BioPlex,STRINGDB
FBXO2
Tbio
Novelty: 0.01578361
p_int: 0.885449872
p_ni: 0.114489407
p_wrong: 0.000060721
Score: 0.571
Data Source: BioPlex,STRINGDB
ERO1B
Tbio
Novelty: 0.06389159
p_int: 0.856413822
p_ni: 0.143586173
p_wrong: 5e-9
Score: 0.665
Data Source: BioPlex,STRINGDB
COL14A1
Tbio
Novelty: 0.01760399
p_int: 0.850661751
p_ni: 0.149338249
Data Source: BioPlex
Publication Statistics
PubMed Score  74.19

PubMed score by year
PubTator Score  27.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer