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Tbio
G6PC2
Glucose-6-phosphatase 2

Protein Summary
Description
May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282075
  • ENSP00000282075
  • ENSG00000152254
  • ENST00000375363
  • ENSP00000364512
  • ENST00000429379
  • ENSP00000396939
  • ENST00000612807
  • ENSP00000481098
  • ENSG00000278373
  • ENST00000617403
  • ENSP00000483899
  • ENST00000622133
  • ENSP00000482583

Symbol
  • IGRP
  • IGRP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
cellular component
0.66
phenotype
0.64
microRNA
0.62
disease
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.81   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.81   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (38)
Items per page:
1 – 5 of 38
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fasting blood glucose measurement
9
2
9
99.6
fasting blood glucose measurement
9
2
9
99.6
HbA1c measurement
3
1
3
96.2
HbA1c measurement
3
1
3
96.2
HOMA-B
1
1
1
90.2
Items per page:
1 – 5 of 38
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fasting blood glucose measurement
9
99.6
fasting blood glucose measurement
9
99.6
HbA1c measurement
3
96.2
HbA1c measurement
3
96.2
HOMA-B
1
90.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1277193
14378
Dog
glucose-6-phosphatase catalytic subunit 2
VGNC:41041
488389
Horse
glucose-6-phosphatase catalytic subunit 2
VGNC:18181
100062750
Cow
glucose-6-phosphatase catalytic subunit 2
VGNC:29179
505012
Platypus
glucose-6-phosphatase catalytic subunit 2
100083297
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
glucose-6-phosphatase catalytic subunit 2
Horse
glucose-6-phosphatase catalytic subunit 2
Cow
glucose-6-phosphatase catalytic subunit 2
Platypus
glucose-6-phosphatase catalytic subunit 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NQR9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Gluconeogenesis (R-HSA-70263)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Gluconeogenesis
Glucose metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (85)
1 – 10 of 85
GCK
Tchem
Family: Kinase
Novelty: 0.00112778
Score: 0.925
Data Source: STRINGDB
LCT
Tbio
Family: Enzyme
Novelty: 0.0019382
Score: 0.913
Data Source: STRINGDB
GPI
Tbio
Family: Enzyme
Novelty: 0.00095404
Score: 0.911
Data Source: STRINGDB
PGM1
Tbio
Family: Enzyme
Novelty: 0.00163947
Score: 0.907
Data Source: STRINGDB
GALM
Tbio
Family: Enzyme
Novelty: 0.01067063
Score: 0.904
Data Source: STRINGDB
PGM2
Tbio
Family: Enzyme
Novelty: 0.00922421
Score: 0.904
Data Source: STRINGDB
GLB1
Tchem
Family: Enzyme
Novelty: 0.00241713
Score: 0.902
Data Source: STRINGDB
HK1
Tchem
Family: Kinase
Novelty: 0.00195554
Score: 0.87
Data Source: STRINGDB
G6PD
Tchem
Family: Enzyme
Novelty: 0.00064455
Score: 0.862
Data Source: STRINGDB
ALDOB
Tbio
Family: Enzyme
Novelty: 0.00856695
Score: 0.861
Data Source: STRINGDB
Publication Statistics
PubMed Score  82.81

PubMed score by year
PubTator Score  49.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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