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Tbio
DMRT3
Doublesex- and mab-3-related transcription factor 3

Protein Summary
Description
Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000190165
  • ENSP00000190165
  • ENSG00000064218

Symbol
  • DMRTA3
  • DMRTA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
molecular function
0.79
cell line
0.67
PubMedID
0.63
biological process
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.14   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.14   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
FBLN7
Tbio
Novelty:  0.03423924
Score:  0.61
Data Source:  STRINGDB
KANK1
Tbio
Novelty:  0.02077359
Score:  0.596
Data Source:  STRINGDB
FOXL2
Tbio
Family:  TF
Novelty:  0.00224046
Score:  0.58
Data Source:  STRINGDB
FOXD4
Tbio
Family:  TF
Novelty:  0.11166611
Score:  0.53
Data Source:  STRINGDB
FZD9
Tbio
Family:  GPCR
Novelty:  0.01414546
Score:  0.527
Data Source:  STRINGDB
AMH
Tbio
Novelty:  0.00022501
Score:  0.525
Data Source:  STRINGDB
GATA4
Tbio
Family:  TF
Novelty:  0.00094282
Score:  0.488
Data Source:  STRINGDB
SOX3
Tbio
Family:  TF
Novelty:  0.00280653
Score:  0.485
Data Source:  STRINGDB
SRD5A3
Tbio
Family:  Enzyme
Novelty:  0.02896703
Score:  0.482
Data Source:  STRINGDB
MMRN1
Tbio
Novelty:  0.03378128
Score:  0.48
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.9
75.7
sex hormone-binding globulin measurement
4
2
4
70
3
3
2
1
64
reticulocyte count
1
1
1
40.7
reticulocyte measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
75.7
sex hormone-binding globulin measurement
4
70
2
1
64
reticulocyte count
1
40.7
reticulocyte measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
doublesex and mab-3 related transcription factor 3
VGNC:4676
473145
Mouse
MGI:2449470
240590
Rat
RGD:1306043
293976
Dog
doublesex and mab-3 related transcription factor 3
VGNC:49682
609208
Cow
doublesex and mab-3 related transcription factor 3
VGNC:28112
506833
Species
Name
OMA
EggNOG
Inparanoid
Chimp
doublesex and mab-3 related transcription factor 3
Mouse
Rat
Dog
doublesex and mab-3 related transcription factor 3
Cow
doublesex and mab-3 related transcription factor 3
Publication Statistics
PubMed Score 50.14
PubMed score by year
PubTator Score 5.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title