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Tbio
Q9NQG6
Mitochondrial dynamics protein MID51

Protein Summary
Description
Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325301
  • ENSP00000327124
  • ENSG00000100335
  • ENST00000404569
  • ENSP00000385191
  • ENST00000428069
  • ENSP00000413730
  • ENST00000433117
  • ENSP00000404096

Symbol
  • MID51
  • SMCR7L
  • MID51
  • SMCR7L
  • AltMIEF1
  • HSU79252
  • MIEF1-MP
  • dJ1104E15.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.38   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.38   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (67)
MAB21L2
Tbio
Novelty:  0.05770595
p_int:  0.999998927
p_ni:  1.65e-7
p_wrong:  9.08e-7
Score:  0.521
Data Source:  BioPlex,STRINGDB
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
p_int:  0.99997423
p_ni:  2.6e-8
p_wrong:  0.000025744
Score:  0.485
Data Source:  BioPlex,STRINGDB
WDFY2
Tbio
Novelty:  0.01835759
p_int:  0.992877922
p_ni:  0.000001432
p_wrong:  0.007120646
Score:  0.202
Data Source:  BioPlex,STRINGDB
FIS1
Tbio
Novelty:  0.0033607
Score:  0.931
Data Source:  STRINGDB
MFF
Tbio
Novelty:  0.00411615
Score:  0.896
Data Source:  STRINGDB
DNM1L
Tchem
Novelty:  0.00151314
Score:  0.843
Data Source:  STRINGDB
MFN1
Tbio
Novelty:  0.00372574
Score:  0.77
Data Source:  STRINGDB
MB21D2
Tdark
Novelty:  0.48908631
Score:  0.723
Data Source:  STRINGDB
MFN2
Tbio
Novelty:  0.00137876
Score:  0.711
Data Source:  STRINGDB
OPA1
Tchem
Novelty:  0.0031868
Score:  0.704
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum IgG glycosylation measurement
2
2
6
96.1
serum IgG glycosylation measurement
2
2
6
96.1
intelligence
5
11
18
5.7
90.9
intelligence
5
11
18
5.7
90.9
schizophrenia
9
7
8
1.1
90.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum IgG glycosylation measurement
6
96.1
serum IgG glycosylation measurement
6
96.1
intelligence
18
5.7
90.9
intelligence
18
5.7
90.9
schizophrenia
8
1.1
90.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial elongation factor 1
VGNC:5281
744438
Macaque
mitochondrial elongation factor 1
703747
Mouse
MGI:2146020
239555
Rat
RGD:1359173
315141
Dog
mitochondrial elongation factor 1
VGNC:43226
610014
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial elongation factor 1
Macaque
mitochondrial elongation factor 1
Mouse
Rat
Dog
mitochondrial elongation factor 1
Publication Statistics
PubMed Score 40.38
PubMed score by year
PubTator Score 11.55
PubTator score by year
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Related Publications
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PMID
Year
Title