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Tbio
RPRD1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

Protein Summary
Description
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373433
  • ENSP00000362532
  • ENSG00000101413

Symbol
  • C20orf77
  • CREPT
  • K-H
  • CREPT
  • NET60
  • C20orf77
  • Kub5-Hera
  • dJ1057B20.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor binding site profile
0.86
drug perturbation
0.71
microRNA
0.7
transcription factor
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.97   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.97   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autosomal dominant compelling helio-ophthalmic outburst syndrome
1
1
0
1.1
80.2
heart rate
1
1
1
79.1
electrocardiography
1
1
18
71.9
pulse pressure measurement
1
1
1
48.5
RR interval
1
1
0
6.6
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autosomal dominant compelling helio-ophthalmic outburst syndrome
0
1.1
80.2
heart rate
1
79.1
electrocardiography
18
71.9
pulse pressure measurement
1
48.5
RR interval
0
6.6
26.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulation of nuclear pre-mRNA domain containing 1B
VGNC:6258
469936
Macaque
regulation of nuclear pre-mRNA domain containing 1B
700056
Mouse
MGI:1917720
70470
Rat
RGD:1304782
311591
Dog
regulation of nuclear pre-mRNA domain containing 1B
VGNC:45727
485866
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulation of nuclear pre-mRNA domain containing 1B
Macaque
regulation of nuclear pre-mRNA domain containing 1B
Mouse
Rat
Dog
regulation of nuclear pre-mRNA domain containing 1B
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NQG5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (118)
1 – 10 of 118
RPRD1A
Tbio
Novelty:  0.13521196
p_int:  1
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
POLR2M
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.999999999
p_ni:  1e-9
Score:  0.827
Data Source:  BioPlex,STRINGDB
RPRD2
Tdark
Novelty:  0.45063764
p_int:  0.999999997
p_ni:  3e-9
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
POLR2D
Tdark
Family:  Enzyme
Novelty:  0.11021614
p_int:  0.999999987
p_ni:  1.3e-8
Score:  0.98
Data Source:  BioPlex,STRINGDB
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.985
Data Source:  BioPlex,STRINGDB
CTDP1
Tbio
Family:  Enzyme
Novelty:  0.01121863
p_int:  0.999999082
p_ni:  1e-7
p_wrong:  8.19e-7
Score:  0.855
Data Source:  BioPlex,STRINGDB
RECQL5
Tbio
Family:  Enzyme
Novelty:  0.01558497
p_int:  0.999998402
p_ni:  0.000001589
p_wrong:  9e-9
Score:  0.858
Data Source:  BioPlex,STRINGDB
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.999910478
p_ni:  0.000089459
p_wrong:  6.3e-8
Score:  0.974
Data Source:  BioPlex,STRINGDB
RPAP2
Tbio
Family:  Enzyme
Novelty:  0.03383659
p_int:  0.99990413
p_ni:  0.00009587
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
p_int:  0.999590487
p_ni:  0.000409513
Score:  0.989
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  29.97

PubMed score by year
PubTator Score  13.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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