Tdark HINT3 Histidine triad nucleotide-binding protein 3

Protein Summary

Description

Hydrolyzes phosphoramidate and acyl-adenylate substrates. Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9NQE9
• B3KQ91
• Q8N0Y9
• HINT-3

Gene Name

• HINT3

Ensembl ID

• ENST00000229633
• ENSP00000229633
• ENSG00000111911

Symbol

• HINT4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
transcription factor binding site profile	0.81
virus perturbation	0.79
cellular component	0.67
tissue sample	0.58

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Damaged Dna-binding Protein / Histidine Triad Nucleotide-binding Protein 3

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Damaged Dna-binding Protein / Histidine Triad Nucleotide-binding Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.37   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 70   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.37   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0