Tdark IFT46 Intraflagellar transport protein 46 homolog

Protein Summary

Description

Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity).

Uniprot Accession IDs

• Q9NQC8
• A8K0F6
• Q9H6V5

Gene Name

• IFT46

Ensembl ID

• ENST00000264020
• ENSP00000264020
• ENSG00000118096
• ENST00000264021
• ENSP00000264021

Symbol

• C11orf2
• C11orf60
• CFAP32
• C11orf2
• C11orf60

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
transcription factor binding site profile	0.87
kinase perturbation	0.76
cell type or tissue	0.61
transcription factor	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.72   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.72   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0