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Tdark
IFT46
Intraflagellar transport protein 46 homolog

Protein Summary
Description
Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264020
  • ENSP00000264020
  • ENSG00000118096
  • ENST00000264021
  • ENSP00000264021

Symbol
  • C11orf2
  • C11orf60
  • CFAP32
  • C11orf2
  • C11orf60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
transcription factor binding site profile
0.87
kinase perturbation
0.76
cell type or tissue
0.61
transcription factor
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.72   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.72   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
TTC30A
Tdark
Novelty:  1.41742212
p_int:  0.999999902
p_ni:  9.7e-8
Score:  0.996
Data Source:  BioPlex,STRINGDB
IFT22
Tbio
Family:  Enzyme
Novelty:  0.18342877
p_int:  0.999999759
p_ni:  2.41e-7
Score:  0.987
Data Source:  BioPlex,STRINGDB
TTC30B
Tbio
Novelty:  0.10944566
p_int:  0.999999733
p_ni:  2.65e-7
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
IFT27
Tbio
Family:  Enzyme
Novelty:  0.05592902
p_int:  0.999999721
p_ni:  2.79e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
IFT57
Tbio
Novelty:  0.03373199
p_int:  0.999973751
p_ni:  0.000026236
p_wrong:  1.3e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
ANKRD55
Tbio
Novelty:  0.09730833
p_int:  0.999937381
p_ni:  0.000062611
p_wrong:  8e-9
Score:  0.843
Data Source:  BioPlex,STRINGDB
ARL13B
Tbio
Family:  Enzyme
Novelty:  0.01481674
p_int:  0.999922478
p_ni:  0.000077511
p_wrong:  1e-8
Score:  0.923
Data Source:  BioPlex,STRINGDB
TFPI2
Tbio
Novelty:  0.00475383
p_int:  0.999856195
p_ni:  0.000143743
p_wrong:  6.2e-8
Data Source:  BioPlex
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.99911233
p_ni:  0.000639383
p_wrong:  0.000248286
Data Source:  BioPlex
IFT81
Tbio
Novelty:  0.01610195
p_int:  0.998595989
p_ni:  0.001404002
p_wrong:  8e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Cilium Assembly (R-HSA-5617833)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cilium Assembly
Reactome
Intraflagellar transport
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cilium Assembly
Intraflagellar transport
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
1.4
98.3
6
2
0
1.3
97.8
alkaline phosphatase measurement
3
3
2
13
92.9
heel bone mineral density
3
1
4
88.9
multiple sclerosis
1
1
0
1.1
77
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
98.3
0
1.3
97.8
alkaline phosphatase measurement
2
13
92.9
heel bone mineral density
4
88.9
multiple sclerosis
0
1.1
77
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1923818
76568
Rat
RGD:1307682
300675
Dog
intraflagellar transport 46
VGNC:41887
479416
Horse
intraflagellar transport 46
VGNC:18961
100063051
Cow
intraflagellar transport 46
VGNC:30069
505579
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
intraflagellar transport 46
Horse
intraflagellar transport 46
Cow
intraflagellar transport 46
Publication Statistics
PubMed Score 12.72
PubMed score by year
PubTator Score 4.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title