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Tbio
RTN4
Reticulon-4

Protein Classes
Protein Summary
Description
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037, PubMed:27619977). Regulates membrane morphogenesis in the ER by promoting tubular ER production (Pub ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317610
  • ENSP00000322147
  • ENSG00000115310
  • ENST00000337526
  • ENSP00000337838
  • ENST00000357376
  • ENSP00000349944
  • ENST00000357732
  • ENSP00000350365
  • ENST00000394609
  • ENSP00000378107
  • ENST00000394611
  • ENSP00000378109
  • ENST00000404909
  • ENSP00000385650
  • ENST00000405240
  • ENSP00000384471

Symbol
  • KIAA0886
  • NOGO
  • ASY
  • NSP
  • NOGO
  • RTN-X
  • NSP-CL
  • RTN4-A
  • RTN4-C
  • RTN4-B1
  • RTN4-B2
  • NI220/250
  • Nbla00271
  • Nbla10545
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.99
kinase perturbation
0.99
transcription factor binding site profile
0.99
co-expressed gene
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1349.07   (req: < 5)
Gene RIFs: 95   (req: <= 3)
Antibodies: 481   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1349.07   (req: >= 5)
Gene RIFs: 95   (req: > 3)
Antibodies: 481   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
93.9
lymphocyte count
2
2
2
70.4
mathematical ability
1
1
1
43.8
body height
1
1
1
32.5
monocyte count
1
1
1
28.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
93.9
lymphocyte count
2
70.4
mathematical ability
1
43.8
body height
1
32.5
monocyte count
1
28.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
reticulon 4
619181
Mouse
MGI:1915835
68585
Rat
RGD:620989
83765
Dog
reticulon 4
VGNC:54541
474598
Horse
reticulon 4
100066612
Species
Name
OMA
EggNOG
Inparanoid
Macaque
reticulon 4
Mouse
Rat
Dog
reticulon 4
Horse
reticulon 4
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Axonal growth inhibition (RHOA activation) (R-HSA-193634)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axonal growth inhibition (RHOA activation)
Reactome
Death Receptor Signalling
Reactome
Signal Transduction
Reactome
p75 NTR receptor-mediated signalling
Reactome
p75NTR regulates axonogenesis
Name
Explore in Pharos
Explore in Source
Axonal growth inhibition (RHOA activation)
Death Receptor Signalling
Signal Transduction
p75 NTR receptor-mediated signalling
p75NTR regulates axonogenesis
Gene Ontology Terms (35)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (200)
1 – 10 of 200
RTN1
Tbio
Novelty: 0.01828064
p_int: 0.99999989
p_ni: 1.1e-7
Score: 0.678
Data Source: BioPlex,STRINGDB
ATP1B2
Tclin
Family: Transporter
Novelty: 0.02641193
p_int: 0.999999181
p_ni: 8.19e-7
Score: 0.34
Data Source: BioPlex,STRINGDB
TMEM128
Tdark
Novelty: 5.15874803
p_int: 0.999997691
p_ni: 0.000002309
Score: 0.641
Data Source: BioPlex,STRINGDB
SPOP
Tbio
Novelty: 0.00663363
p_int: 0.999994994
p_ni: 0.000004969
p_wrong: 3.7e-8
Score: 0.267
Data Source: BioPlex,STRINGDB
ARL6IP1
Tbio
Novelty: 0.07644032
p_int: 0.999994878
p_ni: 0.000005122
Score: 0.631
Data Source: BioPlex,STRINGDB
RABAC1
Tbio
Novelty: 0.01749453
p_int: 0.999960586
p_ni: 0.000015125
p_wrong: 0.000024289
Score: 0.766
Data Source: BioPlex,STRINGDB
TMEM208
Tdark
Novelty: 0.63059333
p_int: 0.99995144
p_ni: 0.000005721
p_wrong: 0.000042839
Score: 0.833
Data Source: BioPlex,STRINGDB
METTL7B
Tbio
Family: Enzyme
Novelty: 0.0873748
p_int: 0.999942679
p_ni: 0.000057192
p_wrong: 1.29e-7
Score: 0.227
Data Source: BioPlex,STRINGDB
RTN2
Tbio
Novelty: 0.05184418
p_int: 0.999906476
p_ni: 0.000093394
p_wrong: 1.3e-7
Score: 0.653
Data Source: BioPlex,STRINGDB
FAM241A
Tdark
Novelty: 1.04041354
p_int: 0.999720597
p_ni: 0.000279388
p_wrong: 1.5e-8
Score: 0.669
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1349.07

PubMed score by year
PubTator Score  1309.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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