Protein Summary
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037, PubMed:27619977). Regulates membrane morphogenesis in the ER by promoting tubular ER production (Pub ...more
- ENST00000317610
- ENSP00000322147
- ENSG00000115310
- ENST00000337526
- ENSP00000337838
- ENST00000357376
- ENSP00000349944
- ENST00000357732
- ENSP00000350365
- ENST00000394609
- ENSP00000378107
- ENST00000394611
- ENSP00000378109
- ENST00000404909
- ENSP00000385650
- ENST00000405240
- ENSP00000384471
- KIAA0886
- NOGO
- ASY
- NSP
- NOGO
- RTN-X
- NSP-CL
- RTN4-A
- RTN4-C
- RTN4-B1
- RTN4-B2
- NI220/250
- Nbla00271
- Nbla10545
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 1 | ||
disease perturbation | 0.99 | ||
kinase perturbation | 0.99 | ||
transcription factor binding site profile | 0.99 | ||
co-expressed gene | 0.97 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1376.91 (req: < 5)
Gene RIFs: 95 (req: <= 3)
Antibodies: 481 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1376.91 (req: >= 5)
Gene RIFs: 95 (req: > 3)
Antibodies: 481 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (200)
RTN1
Novelty: 0.01828064
p_int: 0.99999989
p_ni: 1.1e-7
Score: 0.678
Data Source: BioPlex,STRINGDB
ATP1B2
Family: Transporter
Novelty: 0.02641193
p_int: 0.999999181
p_ni: 8.19e-7
Score: 0.34
Data Source: BioPlex,STRINGDB
TMEM128
Novelty: 5.15874803
p_int: 0.999997691
p_ni: 0.000002309
Score: 0.641
Data Source: BioPlex,STRINGDB
SPOP
Novelty: 0.00663363
p_int: 0.999994994
p_ni: 0.000004969
p_wrong: 3.7e-8
Score: 0.267
Data Source: BioPlex,STRINGDB
ARL6IP1
Novelty: 0.07644032
p_int: 0.999994878
p_ni: 0.000005122
Score: 0.631
Data Source: BioPlex,STRINGDB
RABAC1
Novelty: 0.01749453
p_int: 0.999960586
p_ni: 0.000015125
p_wrong: 0.000024289
Score: 0.766
Data Source: BioPlex,STRINGDB
TMEM208
Novelty: 0.63059333
p_int: 0.99995144
p_ni: 0.000005721
p_wrong: 0.000042839
Score: 0.833
Data Source: BioPlex,STRINGDB
METTL7B
Family: Enzyme
Novelty: 0.0873748
p_int: 0.999942679
p_ni: 0.000057192
p_wrong: 1.29e-7
Score: 0.227
Data Source: BioPlex,STRINGDB
RTN2
Novelty: 0.05184418
p_int: 0.999906476
p_ni: 0.000093394
p_wrong: 1.3e-7
Score: 0.653
Data Source: BioPlex,STRINGDB
FAM241A
Novelty: 1.04041354
p_int: 0.999720597
p_ni: 0.000279388
p_wrong: 1.5e-8
Score: 0.669
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (5)
KEGG (1)
PathwayCommons (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axonal growth inhibition (RHOA activation) | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | Signal Transduction | ||||
Reactome | p75 NTR receptor-mediated signalling | ||||
Reactome | p75NTR regulates axonogenesis | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axonal growth inhibition (RHOA activation) | ||||
Death Receptor Signalling | ||||
Signal Transduction | ||||
p75 NTR receptor-mediated signalling | ||||
p75NTR regulates axonogenesis | ||||
Viral Interactions (0)
Gene Ontology Terms (35)
Functions (3)
Components (11)
Processes (21)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 2 | 3 | 89.7 | |||||
body mass index | 2 | 2 | 2 | 78.7 | |||||
lymphocyte count | 2 | 2 | 2 | 70.4 | |||||
body height | 1 | 1 | 1 | 53.3 | |||||
systolic blood pressure | 2 | 2 | 1 | 5.7 | 40.5 | ||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 89.7 | |||||
body mass index | 2 | 78.7 | |||||
lymphocyte count | 2 | 70.4 | |||||
body height | 1 | 53.3 | |||||
systolic blood pressure | 1 | 5.7 | 40.5 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | reticulon 4 | 619181 | ||||||
Mouse | MGI:1915835 | 68585 | ||||||
Rat | RGD:620989 | 83765 | ||||||
Dog | reticulon 4 | VGNC:54541 | 474598 | |||||
Horse | reticulon 4 | 100066612 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | reticulon 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | reticulon 4 | |||||
Horse | reticulon 4 | |||||
Publication Statistics
PubMed Score 1376.91
PubMed score by year
PubTator Score 1309.30
PubTator score by year
Related Publications
Text Mined References (149)
GeneRif Annotations (95)
Items per page:
0 of 0
PMID | Year | Title |
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