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Tbio
TCF7L2
Transcription factor 7-like 2

Protein Summary
Description
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.97
transcription factor
0.94
transcription factor perturbation
0.94
trait
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 654.96   (req: < 5)
Gene RIFs: 528   (req: <= 3)
Antibodies: 402   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 654.96   (req: >= 5)
Gene RIFs: 528   (req: > 3)
Antibodies: 402   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (38)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
40
10
7
1.4
100
body mass index
12
4
18
98.7
healthspan
1
1
1
96.2
heel bone mineral density
3
3
4
96.1
sex hormone-binding globulin measurement
3
2
3
95.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
1.4
100
body mass index
18
98.7
healthspan
1
96.2
heel bone mineral density
4
96.1
sex hormone-binding globulin measurement
3
95.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor 7 like 2
VGNC:7267
450743
Macaque
transcription factor 7 like 2
701759
Mouse
MGI:1202879
21416
Rat
RGD:1583621
679869
Dog
transcription factor 7 like 2
VGNC:47200
486894
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor 7 like 2
Macaque
transcription factor 7 like 2
Mouse
Rat
Dog
transcription factor 7 like 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NQB0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (79)
Beta-catenin independent WNT signaling (R-HSA-3858494)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Binding of TCF/LEF:CTNNB1 to target gene promoters
Reactome
Ca2+ pathway
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Degradation of beta-catenin by the destruction complex
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Binding of TCF/LEF:CTNNB1 to target gene promoters
Ca2+ pathway
Deactivation of the beta-catenin transactivating complex
Degradation of beta-catenin by the destruction complex
Gene Ontology Terms (49)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (281)
1 – 10 of 281
IKZF5
Tbio
Family: TF
Novelty: 0.36596327
p_int: 0.999996732
p_wrong: 0.000003267
Score: 0.265
Data Source: BioPlex,STRINGDB
PRMT6
Tchem
Family: Epigenetic
Novelty: 0.01734208
p_int: 0.920326458
p_ni: 0.079672501
p_wrong: 0.000001041
Score: 0.209
Data Source: BioPlex,STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.998
Data Source: Reactome,STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.992
Data Source: Reactome,STRINGDB
NLK
Tchem
Family: Kinase
Novelty: 0.01512201
Score: 0.988
Data Source: Reactome,STRINGDB
AXIN2
Tchem
Novelty: 0.00273189
Score: 0.987
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.987
Data Source: Reactome,STRINGDB
TLE3
Tbio
Novelty: 0.02641884
Score: 0.985
Data Source: Reactome,STRINGDB
TLE4
Tbio
Novelty: 0.02094922
Score: 0.983
Data Source: Reactome,STRINGDB
TLE1
Tbio
Novelty: 0.00594261
Score: 0.983
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  654.96

PubMed score by year
PubTator Score  542.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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