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Tbio
TCF7L2
Transcription factor 7-like 2

Protein Summary
Description
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352065
  • ENSP00000344823
  • ENSG00000148737
  • ENST00000355717
  • ENSP00000347949
  • ENST00000355995
  • ENSP00000348274
  • ENST00000369397
  • ENSP00000358404
  • ENST00000538897
  • ENSP00000446172
  • ENST00000627217
  • ENSP00000486891

Symbol
  • TCF4
  • TCF4
  • TCF-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.97
transcription factor
0.94
transcription factor perturbation
0.94
trait
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 682.24   (req: < 5)
Gene RIFs: 528   (req: <= 3)
Antibodies: 402   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 682.24   (req: >= 5)
Gene RIFs: 528   (req: > 3)
Antibodies: 402   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (281)
IKZF5
Tbio
Family:  TF
Novelty:  0.36596327
p_int:  0.999996732
p_wrong:  0.000003267
Score:  0.265
Data Source:  BioPlex,STRINGDB
PRMT6
Tchem
Family:  Epigenetic
Novelty:  0.01734208
p_int:  0.920326458
p_ni:  0.079672501
p_wrong:  0.000001041
Score:  0.209
Data Source:  BioPlex,STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.998
Data Source:  Reactome,STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.992
Data Source:  Reactome,STRINGDB
NLK
Tchem
Family:  Kinase
Novelty:  0.01512201
Score:  0.988
Data Source:  Reactome,STRINGDB
AXIN2
Tchem
Novelty:  0.00273189
Score:  0.987
Data Source:  STRINGDB
CREBBP
Tchem
Family:  Epigenetic
Novelty:  0.00111166
Score:  0.987
Data Source:  Reactome,STRINGDB
TLE3
Tbio
Novelty:  0.02641884
Score:  0.985
Data Source:  Reactome,STRINGDB
TLE4
Tbio
Novelty:  0.02094922
Score:  0.983
Data Source:  Reactome,STRINGDB
TLE1
Tbio
Novelty:  0.00594261
Score:  0.983
Data Source:  Reactome,STRINGDB
Pathways (79)
Beta-catenin independent WNT signaling (R-HSA-3858494)

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Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Binding of TCF/LEF:CTNNB1 to target gene promoters
Reactome
Ca2+ pathway
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Degradation of beta-catenin by the destruction complex
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Binding of TCF/LEF:CTNNB1 to target gene promoters
Ca2+ pathway
Deactivation of the beta-catenin transactivating complex
Degradation of beta-catenin by the destruction complex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (49)
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Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
41
13
7
1.4
99.9
glucose measurement
5
9
9
96.9
Drugs used in diabetes use measurement
1
2
2
95.6
HbA1c measurement
4
10
10
94.9
heel bone mineral density
3
2
3
92
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
1.4
99.9
glucose measurement
9
96.9
Drugs used in diabetes use measurement
2
95.6
HbA1c measurement
10
94.9
heel bone mineral density
3
92
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transcription factor 7 like 2
VGNC:7267
450743
Macaque
transcription factor 7 like 2
701759
Mouse
MGI:1202879
21416
Rat
RGD:1583621
679869
Dog
transcription factor 7 like 2
VGNC:47200
486894
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transcription factor 7 like 2
Macaque
transcription factor 7 like 2
Mouse
Rat
Dog
transcription factor 7 like 2
Publication Statistics
PubMed Score 682.24
PubMed score by year
PubTator Score 542.12
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title