TRPV5
Transient receptor potential cation channel subfamily V member 5
Protein Classes
Protein Summary
Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated ...more
- ENST00000442623
- ENSP00000406572
- ENSG00000127412
- ECAC1
- CAT2
- ECAC1
- OTRPC3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
molecular function | 0.7 | ||
biological term | 0.55 | ||
cell line | 0.53 | ||
phenotype | 0.51 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 181.49 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 274 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 181.49 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 274 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
1 | 1 | 1 | 47 | ||||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
1 | 47 | ||||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transient receptor potential cation channel subfamily V member 5 | VGNC:14104 | 463800 | |||||
Macaque | transient receptor potential cation channel subfamily V member 5 | 705218 | ||||||
Mouse | MGI:2429764 | 194352 | ||||||
Rat | RGD:620636 | 116469 | ||||||
Dog | transient receptor potential cation channel subfamily V member 5 | VGNC:47885 | 100855561 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | transient receptor potential cation channel subfamily V member 5 | |||||
Macaque | transient receptor potential cation channel subfamily V member 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | transient receptor potential cation channel subfamily V member 5 | |||||
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (73)
Reactome (4)
KEGG (2)
WikiPathways (67)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ion channel transport | ||||
Reactome | Stimuli-sensing channels | ||||
Reactome | TRP channels | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ion channel transport | ||||
Stimuli-sensing channels | ||||
TRP channels | ||||
Transport of small molecules | ||||
Gene Ontology Terms (14)
Functions (4)
Components (3)
Processes (7)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (90)
1 – 10 of 90
UHRF1
Family: Epigenetic
Novelty: 0.00482565
p_int: 0.999741611
p_ni: 0.00025838
p_wrong: 8e-9
Score: 0.163
Data Source: BioPlex,STRINGDB
STAT3
Family: TF
Novelty: 0.00011808
p_int: 0.999243042
p_ni: 0.000756958
Score: 0.201
Data Source: BioPlex,STRINGDB
PUS1
Family: Enzyme
Novelty: 0.01923618
p_int: 0.997533593
p_ni: 0.002466407
Score: 0.225
Data Source: BioPlex,STRINGDB
RPIA
Family: Enzyme
Novelty: 0.00968705
p_int: 0.995142468
p_ni: 0.002894207
p_wrong: 0.001963326
Score: 0.19
Data Source: BioPlex,STRINGDB
UBE3A
Family: Enzyme
Novelty: 0.00149368
p_int: 0.989367351
p_ni: 0.010621961
p_wrong: 0.000010689
Score: 0.204
Data Source: BioPlex,STRINGDB
GCLM
Family: Enzyme
Novelty: 0.00395815
p_int: 0.965431228
p_ni: 0.001727511
p_wrong: 0.032841261
Score: 0.207
Data Source: BioPlex,STRINGDB
ATF1
Family: TF
Novelty: 0.01450941
p_int: 0.963090246
p_ni: 0.000332277
p_wrong: 0.036577477
Score: 0.207
Data Source: BioPlex,STRINGDB
YY1
Family: TF
Novelty: 0.00120891
p_int: 0.954340886
p_ni: 0.045293936
p_wrong: 0.000365178
Score: 0.19
Data Source: BioPlex,STRINGDB
NUP35
Novelty: 0.0355102
p_int: 0.923107725
p_ni: 0.076892218
p_wrong: 5.7e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
RNF138
Family: TF
Novelty: 0.07543428
p_int: 0.912969698
p_ni: 0.067037279
p_wrong: 0.019993023
Score: 0.19
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 181.49
PubMed score by year
PubTator Score 113.14
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword