Tchem TRPV5 Transient receptor potential cation channel subfamily V member 5

Protein Summary

Description

Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NQA5
• A4D2H7
• E9PBZ6
• Q8N4C1
• Q8NDW5
• Q8NDX7
• Q8NDX8
• Q96PM6
• TrpV5

Gene Name

• TRPV5

Ensembl ID

• ENST00000442623
• ENSP00000406572
• ENSG00000127412

Symbol

• ECAC1
• CAT2
• ECAC1
• OTRPC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
molecular function	0.7
biological term	0.55
cell line	0.53
phenotype	0.51

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Transient Receptor Potential Cation Channel Subfamily V Member 5

DTO Classes

Protein / Ion Channel / Transient Receptor Potential Calcium Channel (Trp-cc) Family / Trpv Subfamily / Trpv5 Sub-subfamily / Transient Receptor Potential Cation Channel Subfamily V Member 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.26   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 274   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 184.26   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 274   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

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1 – 1 of 1

ruthenium red

TRPV5Tchem IC

: 7

Protein-Protein Interactions (90)

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1 – 10 of 90

• See Interactions on String-DB

UHRF1

Tbio

Family:  Epigenetic

Novelty:  0.00482565

p_int:  0.999741611

p_ni:  0.00025838

p_wrong:  8e-9

Score:  0.163

Data Source:  BioPlex,STRINGDB

STAT3

Tchem

Family:  TF

Novelty:  0.00011808

p_int:  0.999243042

p_ni:  0.000756958

Score:  0.201

Data Source:  BioPlex,STRINGDB

PUS1

Tbio

Family:  Enzyme

Novelty:  0.01923618

p_int:  0.997533593

p_ni:  0.002466407

Score:  0.225

Data Source:  BioPlex,STRINGDB

RPIA

Tbio

Family:  Enzyme

Novelty:  0.00968705

p_int:  0.995142468

p_ni:  0.002894207

p_wrong:  0.001963326

Score:  0.19

Data Source:  BioPlex,STRINGDB

UBE3A

Tbio

Family:  Enzyme

Novelty:  0.00149368

p_int:  0.989367351

p_ni:  0.010621961

p_wrong:  0.000010689

Score:  0.204

Data Source:  BioPlex,STRINGDB

GCLM

Tbio

Family:  Enzyme

Novelty:  0.00395815

p_int:  0.965431228

p_ni:  0.001727511

p_wrong:  0.032841261

Score:  0.207

Data Source:  BioPlex,STRINGDB

ATF1

Tchem

Family:  TF

Novelty:  0.01450941

p_int:  0.963090246

p_ni:  0.000332277

p_wrong:  0.036577477

Score:  0.207

Data Source:  BioPlex,STRINGDB

YY1

Tbio

Family:  TF

Novelty:  0.00120891

p_int:  0.954340886

p_ni:  0.045293936

p_wrong:  0.000365178

Score:  0.19

Data Source:  BioPlex,STRINGDB

NUP35

Tbio

Novelty:  0.0355102

p_int:  0.923107725

p_ni:  0.076892218

p_wrong:  5.7e-8

Score:  0.173

Data Source:  BioPlex,STRINGDB

RNF138

Tbio

Family:  TF

Novelty:  0.07543428

p_int:  0.912969698

p_ni:  0.067037279

p_wrong:  0.019993023

Score:  0.19

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (2)

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Upstream (2)

1 – 2 of 2

VDR

Tclin

Family:  Nuclear Receptor

KEGG Distance:  1

Common Pathways:  2

1: Parathyroid hormone synthesis, secretion and action

2: Endocrine and other factor-regulated calcium reabsorption

ESR1

Tclin

Family:  Nuclear Receptor

KEGG Distance:  1

Common Pathways:  1

1: Endocrine and other factor-regulated calcium reabsorption

Pathways (73)

Reactome (4)

KEGG (2)

WikiPathways (67)

Ion channel transport (R-HSA-983712)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Ion channel transport	179 targets	R-HSA-983712
Reactome	Stimuli-sensing channels	102 targets	R-HSA-2672351
Reactome	TRP channels	25 targets	R-HSA-3295583
Reactome	Transport of small molecules	725 targets	R-HSA-382551

Name	Explore in Pharos	Explore in Source
Ion channel transport	179 targets	R-HSA-983712
Stimuli-sensing channels	102 targets	R-HSA-2672351
TRP channels	25 targets	R-HSA-3295583
Transport of small molecules	725 targets	R-HSA-382551

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (4)

Components (3)

Processes (7)

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GO Term	Evidence	Assigned by
calcium channel activity	Inferred from Direct Assay (IDA)	UniProtKB
ion channel activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calmodulin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (4)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	2	2	3		80.6
reticulocyte count	EFO_0007986	4	2	4		79.4
HbA1c measurement	EFO_0004541	1	1	1		35
type II diabetes mellitus	EFO_0001360	1	1	1		29

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte measurement	EFO_0010700	3		80.6
reticulocyte count	EFO_0007986	4		79.4
HbA1c measurement	EFO_0004541	1		35
type II diabetes mellitus	EFO_0001360	1		29

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
ANK repeat
Calcium
Calcium channel
Calcium transport
Calmodulin-binding
Cell membrane
Complete proteome
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
HbA1c measurement
reticulocyte count
reticulocyte measurement
type II diabetes mellitus

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
digestive/alimentary phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
renal/urinary system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transient receptor potential cation channel subfamily V member 5	VGNC:14104	463800
Macaque	transient receptor potential cation channel subfamily V member 5		705218
Mouse	transient receptor potential cation channel, subfamily V, member 5	MGI:2429764	194352
Rat	transient receptor potential cation channel, subfamily V, member 5	RGD:620636	116469
Dog	transient receptor potential cation channel subfamily V member 5	VGNC:47885	100855561

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transient receptor potential cation channel subfamily V member 5
Macaque	transient receptor potential cation channel subfamily V member 5
Mouse	transient receptor potential cation channel, subfamily V, member 5
Rat	transient receptor potential cation channel, subfamily V, member 5
Dog	transient receptor potential cation channel subfamily V member 5

Publication Statistics

PubMed Score 184.26

PubMed score by year

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PubTator Score 113.14

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Patents

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Related Publications

Text Mined References (61)

GeneRif Annotations (42)

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PMID	Year	Title