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Tbio
A1CF
APOBEC1 complementation factor

Protein Summary
Description
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA process ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282641
  • ENSP00000282641
  • ENSG00000148584
  • ENST00000373993
  • ENSP00000363105
  • ENST00000373995
  • ENSP00000363107
  • ENST00000373997
  • ENSP00000363109
  • ENST00000374001
  • ENSP00000363113
  • ENST00000395495
  • ENSP00000378873

Symbol
  • ACF
  • ASP
  • ACF
  • ASP
  • ACF64
  • ACF65
  • APOBEC1CF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.94
cell type or tissue
0.7
interacting protein
0.64
virus perturbation
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.09   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.09   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (101)
1 – 10 of 101
PSMG2
Tbio
Novelty:  0.11082503
p_int:  0.939937999
p_ni:  0.060035222
p_wrong:  0.000026779
Score:  0.816
Data Source:  BioPlex,STRINGDB
PSMG3
Tchem
Novelty:  0.01730294
p_int:  0.796782453
p_ni:  0.203178548
p_wrong:  0.000038999
Score:  0.683
Data Source:  BioPlex,STRINGDB
APOBEC1
Tbio
Novelty:  0.00622042
Score:  0.992
Data Source:  Reactome,STRINGDB
APOBEC4
Tdark
Novelty:  0.13240154
Score:  0.947
Data Source:  STRINGDB
APOBEC2
Tbio
Novelty:  0.03447716
Score:  0.943
Data Source:  STRINGDB
APOBEC3H
Tbio
Novelty:  0.01600106
Score:  0.926
Data Source:  STRINGDB
APOBEC3C
Tbio
Novelty:  0.00882074
Score:  0.926
Data Source:  STRINGDB
APOBEC3B
Tbio
Novelty:  0.008531
Score:  0.926
Data Source:  STRINGDB
APOBEC3A
Tchem
Novelty:  0.00982993
Score:  0.92
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.861
Data Source:  STRINGDB
Pathways (4)
Formation of the Editosome (R-HSA-75094)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of the Editosome
Reactome
Metabolism of RNA
Reactome
mRNA Editing
Reactome
mRNA Editing: C to U Conversion
Name
Explore in Pharos
Explore in Source
Formation of the Editosome
Metabolism of RNA
mRNA Editing
mRNA Editing: C to U Conversion
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
6
6
8
97.6
glomerular filtration rate
7
4
6
6.5
92.1
creatinine measurement
3
3
3
83.6
triglyceride measurement
5
1
5
77.1
apolipoprotein B measurement
1
1
1
75.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
8
97.6
glomerular filtration rate
6
6.5
92.1
creatinine measurement
3
83.6
triglyceride measurement
5
77.1
apolipoprotein B measurement
1
75.2
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
APOBEC1 complementation factor
VGNC:3792
466076
Macaque
APOBEC1 complementation factor
703806
Mouse
MGI:1917115
69865
Rat
RGD:619834
170912
Dog
APOBEC1 complementation factor
VGNC:37399
477581
Species
Name
OMA
EggNOG
Inparanoid
Chimp
APOBEC1 complementation factor
Macaque
APOBEC1 complementation factor
Mouse
Rat
Dog
APOBEC1 complementation factor
Publication Statistics
PubMed Score 24.09
PubMed score by year
PubTator Score 12.29
PubTator score by year