You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
COPRS
Coordinator of PRMT5 and differentiation stimulator

Protein Summary
Description
Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302362
  • ENSP00000304327
  • ENSG00000172301

Symbol
  • C17orf79
  • COPR5
  • TTP1
  • COPR5
  • C17orf79
  • HSA272196
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
histone modification site profile
0.7
biological process
0.61
cell line
0.61
tissue sample
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.44   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 5   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.44   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
WIZ
Tbio
Family:  TF
Novelty:  0.04458547
p_int:  0.999998217
p_ni:  0.000001783
Data Source:  BioPlex
RIOK1
Tchem
Family:  Kinase
Novelty:  0.02476698
p_int:  0.999960062
p_ni:  0.000039938
Score:  0.586
Data Source:  BioPlex,STRINGDB
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.999934218
p_ni:  0.000065782
Data Source:  BioPlex
PRMT5
Tchem
Family:  Epigenetic
Novelty:  0.00395474
p_int:  0.999928797
p_ni:  0.000071204
Score:  0.986
Data Source:  BioPlex,Reactome,STRINGDB
RPL15
Tbio
Novelty:  0.02466708
p_int:  0.9999175
p_ni:  0.000070954
p_wrong:  0.000011546
Data Source:  BioPlex
RBFOX2
Tbio
Novelty:  0.00856339
p_int:  0.99989912
p_ni:  0.000062219
p_wrong:  0.000038662
Data Source:  BioPlex
LSM6
Tbio
Novelty:  0.09507671
p_int:  0.999759592
p_ni:  0.000229204
p_wrong:  0.000011204
Data Source:  BioPlex
CHTOP
Tbio
Novelty:  0.04170391
p_int:  0.999724266
p_ni:  0.000085927
p_wrong:  0.000189807
Data Source:  BioPlex
SNRPB
Tbio
Novelty:  0.01503535
p_int:  0.999671996
p_ni:  0.00015935
p_wrong:  0.000168654
Data Source:  BioPlex
RPS2
Tbio
Novelty:  0.00412313
p_int:  0.999538471
p_ni:  0.000461301
p_wrong:  2.28e-7
Score:  0.155
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
RMTs methylate histone arginines
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
RMTs methylate histone arginines
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
7.3
albuminuria
1
1
0
34.1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
7.3
albuminuria
0
34.1
1.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
coordinator of PRMT5 and differentiation stimulator
VGNC:10071
748417
Macaque
coordinator of PRMT5 and differentiation stimulator
713293
Mouse
MGI:1913673
66423
Rat
RGD:1565675
290925
Dog
coordinator of PRMT5 and differentiation stimulator [Source:HGNC Symbol;Acc:HGNC:28848]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
coordinator of PRMT5 and differentiation stimulator
Macaque
coordinator of PRMT5 and differentiation stimulator
Mouse
Rat
Dog
coordinator of PRMT5 and differentiation stimulator [Source:HGNC Symbol;Acc:HGNC:28848]
Publication Statistics
PubMed Score 28.44
PubMed score by year
PubTator Score 3.09
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title