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Tbio
TIGAR
Fructose-2,6-bisphosphatase TIGAR

Protein Summary
Description
Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (PubMed:19015259). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production (PubMed:16839880, PubMed:22887998). Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death (PubMed:16839880, PubMed:19713938, PubMed:23726973, PubMed:22887998, PubMed:23817040). Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity (PubMed:23185017). In response to cardiac damage stress, mediates p53-induced inhibition of myocy ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000179259
  • ENSP00000179259
  • ENSG00000078237

Symbol
  • C12orf5
  • FR2BP
  • C12orf5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
PubMedID
0.73
transcription factor binding site profile
0.73
histone modification site profile
0.71
transcription factor
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.44   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 134.44   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (54)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
8
3
1.1
99.1
mean corpuscular volume
3
3
3
94.7
erythrocyte count
4
4
4
92.5
hematocrit
3
3
3
90.3
9
6
0
1.1
90.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
99.1
mean corpuscular volume
3
94.7
erythrocyte count
4
92.5
hematocrit
3
90.3
0
1.1
90.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TP53 induced glycolysis regulatory phosphatase
VGNC:5622
466924
Macaque
TP53 induced glycolysis regulatory phosphatase
721886
Mouse
MGI:2442752
319801
Dog
TP53 induced glycolysis regulatory phosphatase
VGNC:47368
486736
Horse
TP53 induced glycolysis regulatory phosphatase
VGNC:24103
100058416
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TP53 induced glycolysis regulatory phosphatase
Macaque
TP53 induced glycolysis regulatory phosphatase
Mouse
Dog
TP53 induced glycolysis regulatory phosphatase
Horse
TP53 induced glycolysis regulatory phosphatase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NQ88-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Metabolic Genes
Reactome
Transcriptional Regulation by TP53
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Metabolic Genes
Transcriptional Regulation by TP53
Protein-Protein Interactions (102)
1 – 10 of 102
PNPLA4
Tbio
Family:  Enzyme
Novelty:  0.07471752
p_int:  0.756297969
p_ni:  0.157367165
p_wrong:  0.086334865
Score:  0.496
Data Source:  BioPlex,STRINGDB
TWF1
Tbio
Novelty:  0.03535316
p_int:  0.756297969
p_ni:  0.157367165
p_wrong:  0.086334865
Score:  0.485
Data Source:  BioPlex,STRINGDB
PFKFB4
Tchem
Family:  Enzyme
Novelty:  0.02847966
Score:  0.993
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.984
Data Source:  STRINGDB
PFKFB3
Tchem
Family:  Kinase
Novelty:  0.00333471
Score:  0.973
Data Source:  STRINGDB
PFKFB2
Tchem
Family:  Kinase
Novelty:  0.01603779
Score:  0.969
Data Source:  STRINGDB
PFKFB1
Tbio
Family:  Kinase
Novelty:  0.03400219
Score:  0.958
Data Source:  STRINGDB
HK2
Tchem
Family:  Kinase
Novelty:  0.00144136
Score:  0.918
Data Source:  STRINGDB
PFKM
Tbio
Family:  Kinase
Novelty:  0.00217816
Score:  0.917
Data Source:  STRINGDB
MPI
Tchem
Family:  Enzyme
Novelty:  0.0091718
Score:  0.908
Data Source:  STRINGDB
Publication Statistics
PubMed Score  134.44

PubMed score by year
PubTator Score  58.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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