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Tbio
HEYL
Hairy/enhancer-of-split related with YRPW motif-like protein

Protein Summary
Description
Downstream effector of Notch signaling which may be required for cardiovascular development (By similarity). Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372852
  • ENSP00000361943
  • ENSG00000163909

Symbol
  • BHLHB33
  • HRT3
  • HEY3
  • HRT3
  • HESR3
  • bHLHb33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.96
microRNA
0.59
hub protein
0.58
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.02   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 298   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.02   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 298   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (77)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (R-HSA-2894862)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
NOTCH1 Intracellular Domain Regulates Transcription
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Disease
Diseases of signal transduction
NOTCH1 Intracellular Domain Regulates Transcription
Gene Ontology Terms (42)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (39)
1 – 10 of 39
PGGT1B
Tchem
Family: Enzyme
Novelty: 0.08041103
p_int: 0.99999909
p_ni: 6.39e-7
p_wrong: 2.71e-7
Score: 0.534
Data Source: BioPlex,STRINGDB
ARL10
Tdark
Family: Enzyme
Novelty: 1.16329406
p_int: 0.999038732
p_ni: 0.000961268
Score: 0.258
Data Source: BioPlex,STRINGDB
FNTA
Tbio
Family: Enzyme
Novelty: 0.03163169
p_int: 0.994862356
p_ni: 0.005137644
Score: 0.534
Data Source: BioPlex,STRINGDB
NOTCH3
Tchem
Novelty: 0.000953
Score: 0.968
Data Source: STRINGDB
NOTCH1
Tchem
Novelty: 0.00012547
Score: 0.967
Data Source: STRINGDB
RBPJ
Tbio
Family: TF
Novelty: 0.00168834
Score: 0.966
Data Source: STRINGDB
MAML1
Tbio
Novelty: 0.01302751
Score: 0.94
Data Source: STRINGDB
MAML2
Tbio
Novelty: 0.00836375
Score: 0.925
Data Source: STRINGDB
MAML3
Tbio
Novelty: 0.05574812
Score: 0.915
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.914
Data Source: STRINGDB
Publication Statistics
PubMed Score  145.02

PubMed score by year
PubTator Score  84.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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