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Tbio
GPRC5C
G-protein coupled receptor family C group 5 member C

Protein Summary
Description
This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000392629
  • ENSP00000376405
  • ENSG00000170412

Symbol
  • RAIG3
  • RAIG3
  • RAIG-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.89
PubMedID
0.86
gene perturbation
0.83
cell type or tissue
0.76
histone modification site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.54   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.54   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (53)
1 – 10 of 53
GOLPH3L
Tbio
Novelty:  0.30373124
p_int:  0.999999334
p_ni:  6.65e-7
p_wrong:  1e-9
Data Source:  BioPlex
NMT2
Tchem
Family:  Enzyme
Novelty:  0.04826835
p_int:  0.999997128
p_ni:  0.000002869
p_wrong:  3e-9
Data Source:  BioPlex
PCYT1A
Tchem
Family:  Enzyme
Novelty:  0.00621528
p_int:  0.999985555
p_ni:  0.000014445
Score:  0.181
Data Source:  BioPlex,STRINGDB
BAIAP2L1
Tbio
Novelty:  0.06381886
p_int:  0.999984937
p_ni:  0.000015055
p_wrong:  9e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
NMT1
Tchem
Family:  Enzyme
Novelty:  0.00343834
p_int:  0.999349867
p_ni:  0.000650133
Data Source:  BioPlex
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.999341586
p_ni:  0.000658413
p_wrong:  1e-9
Data Source:  BioPlex
GOLPH3
Tbio
Novelty:  0.00020234
p_int:  0.995890483
p_ni:  0.004108252
p_wrong:  0.000001265
Data Source:  BioPlex
NNT
Tbio
Family:  Enzyme
Novelty:  0.00269343
p_int:  0.994608812
p_ni:  0.005391188
Score:  0.161
Data Source:  BioPlex,STRINGDB
C17orf75
Tbio
Novelty:  0.08706784
p_int:  0.988360049
p_ni:  0.011623903
p_wrong:  0.000016048
Data Source:  BioPlex
FMO1
Tbio
Family:  Enzyme
Novelty:  0.02090294
p_int:  0.964132153
p_ni:  0.03586781
p_wrong:  3.7e-8
Data Source:  BioPlex
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
GPCRs, Class C Metabotropic glutamate, pheromone
Name
Explore in Pharos
Explore in Source
GPCRs, Class C Metabotropic glutamate, pheromone
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
1
1
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
70.5
Find similar targets by:
IDG Resources
Genetic Construct
GPRC5C-Tango
image for GPRC5C-Tango
Details:
  • Vector:  addgene66384
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPRC5C-Tango
Order Genetic Construct from:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1917605
70355
Rat
RGD:1311408
287805
Dog
G protein-coupled receptor class C group 5 member C
483288
Horse
G protein-coupled receptor class C group 5 member C
100060724
Cow
G protein-coupled receptor class C group 5 member C
535664
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
G protein-coupled receptor class C group 5 member C
Horse
G protein-coupled receptor class C group 5 member C
Cow
G protein-coupled receptor class C group 5 member C
Publication Statistics
PubMed Score 5.54
PubMed score by year
PubTator Score 2.14
PubTator score by year
Patents
Patents by year