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Tbio
LHX9
LIM/homeobox protein Lhx9

Protein Summary
Description
Involved in gonadal development. This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367387
  • ENSP00000356357
  • ENSG00000143355
  • ENST00000367390
  • ENSP00000356360
  • ENST00000367391
  • ENSP00000356361
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
transcription factor
0.74
virus perturbation
0.64
PubMedID
0.63
molecular function
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.35   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.35   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Regulation of expression of SLITs and ROBOs
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Regulation of expression of SLITs and ROBOs
Signaling by ROBO receptors
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (73)
1 – 10 of 73
LDB1
Tbio
Novelty: 0.00548345
p_int: 0.998785436
p_ni: 0.001214564
Score: 0.946
Data Source: BioPlex,STRINGDB
SSBP3
Tbio
Novelty: 0.02698795
p_int: 0.972553666
p_ni: 0.001626617
p_wrong: 0.025819717
Score: 0.882
Data Source: BioPlex,STRINGDB
PARP2
Tclin
Family: Enzyme
Novelty: 0.00798241
p_int: 0.872633013
p_ni: 0.127366987
Score: 0.19
Data Source: BioPlex,STRINGDB
ZHX1
Tbio
Family: TF
Novelty: 0.06603742
p_int: 0.790003008
p_ni: 0.000514307
p_wrong: 0.209482685
Score: 0.544
Data Source: BioPlex,STRINGDB
LHX2
Tbio
Family: TF
Novelty: 0.01121748
Score: 0.904
Data Source: STRINGDB
MSI1
Tbio
Novelty: 0.00830008
Score: 0.9
Data Source: STRINGDB
SSBP4
Tdark
Novelty: 0.54545455
Score: 0.833
Data Source: STRINGDB
LDB2
Tbio
Novelty: 0.02330098
Score: 0.74
Data Source: STRINGDB
NR5A1
Tchem
Family: NR
Novelty: 0.00114781
Score: 0.721
Data Source: STRINGDB
GATA4
Tbio
Family: TF
Novelty: 0.00115226
Score: 0.703
Data Source: STRINGDB
Publication Statistics
PubMed Score  31.35

PubMed score by year
PubTator Score  15.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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