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Tbio
PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Protein Classes
Protein Summary
Description
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338037
  • ENSP00000338185
  • ENSG00000182621
  • ENST00000378637
  • ENSP00000367904
  • ENST00000378641
  • ENSP00000367908

Symbol
  • KIAA0581
  • PLC-I
  • EIEE12
  • PI-PLC
  • PLC154
  • PLCB1A
  • PLCB1B
  • PLC-154
  • PLC-beta-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
0.99
molecular function
0.98
transcription factor perturbation
0.91
metabolite
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 385.7   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 385.7   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
1
4
94.9
lymphocyte count
3
2
3
89
mean platelet volume
2
2
2
85.5
monocyte count
3
1
3
83.1
myeloid white cell count
1
1
1
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
94.9
lymphocyte count
3
89
mean platelet volume
2
85.5
monocyte count
3
83.1
myeloid white cell count
1
80.3
Pathways (118)
Acetylcholine regulates insulin secretion (R-HSA-399997)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine regulates insulin secretion
Reactome
Activation of kainate receptors upon glutamate binding
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Name
Explore in Pharos
Explore in Source
Acetylcholine regulates insulin secretion
Activation of kainate receptors upon glutamate binding
Beta-catenin independent WNT signaling
Ca2+ pathway
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Gene Ontology Terms (53)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
AgBase
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (343)
1 – 10 of 343
BTN2A1
Tbio
Novelty: 0.02259329
p_int: 0.999955201
p_ni: 0.000034638
p_wrong: 0.000010161
Score: 0.187
Data Source: BioPlex,STRINGDB
PTGER3
Tclin
Family: GPCR
Novelty: 0.0012681
p_int: 0.999936935
p_ni: 0.000023609
p_wrong: 0.000039456
Score: 0.23
Data Source: BioPlex,STRINGDB
DEF8
Tdark
Novelty: 0.21146806
p_int: 0.999864744
p_ni: 0.000034933
p_wrong: 0.000100323
Score: 0.189
Data Source: BioPlex,STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
Score: 0.99
Data Source: Reactome,STRINGDB
PRKCA
Tchem
Family: Kinase
Novelty: 0.00057611
Score: 0.981
Data Source: STRINGDB
ITPR2
Tbio
Family: IC
Novelty: 0.00619813
Score: 0.963
Data Source: STRINGDB
GNA11
Tbio
Novelty: 0.00128664
Score: 0.961
Data Source: Reactome,STRINGDB
ITPR1
Tchem
Family: IC
Novelty: 0.00111834
Score: 0.956
Data Source: STRINGDB
ITPR3
Tchem
Family: IC
Novelty: 0.00154917
Score: 0.954
Data Source: STRINGDB
GRM5
Tchem
Family: GPCR
Novelty: 0.00062552
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  385.70

PubMed score by year
PubTator Score  384.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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