PPAN
Suppressor of SWI4 1 homolog
Protein Summary
May have a role in cell growth. The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]
- ENST00000253107
- ENSP00000253107
- ENSG00000130810
- BXDC3
- SSF1
- SSF
- SSF1
- SSF2
- BXDC3
- SSF-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell line | 0.66 | ||
tissue sample | 0.5 | ||
disease | 0.45 | ||
tissue | 0.45 | ||
histone modification site profile | 0.43 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 144.53 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 138 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 144.53 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 138 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0