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Tbio
MRPL40
39S ribosomal protein L40, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333130
  • ENSP00000333401
  • ENSG00000185608

Symbol
  • NLVCF
  • URIM
  • URIM
  • L40mt
  • NLVCF
  • MRPL22
  • MRP-L22
  • MRP-L40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
virus perturbation
0.85
interacting protein
0.83
disease perturbation
0.79
transcription factor
0.75


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.69   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.69   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L40
VGNC:5283
470139
Mouse
MGI:1332635
18100
Rat
RGD:1565444
287962
Horse
mitochondrial ribosomal protein L40 [Source:HGNC Symbol;Acc:HGNC:14491]
Cow
mitochondrial ribosomal protein L40
VGNC:31636
101907103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L40
Mouse
Rat
Horse
mitochondrial ribosomal protein L40 [Source:HGNC Symbol;Acc:HGNC:14491]
Cow
mitochondrial ribosomal protein L40
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NQ50-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (203)
1 – 10 of 203
MRPL46
Tdark
Novelty: 0.6199259
p_int: 0.999993188
p_ni: 0.000006812
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL18
Tbio
Novelty: 0.73438796
p_int: 0.999990289
p_ni: 0.000009711
Score: 0.986
Data Source: BioPlex,STRINGDB
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.999977076
p_ni: 0.000022924
Score: 0.997
Data Source: BioPlex,STRINGDB
MRPL30
Tdark
Novelty: 1.03623556
p_int: 0.999888276
p_ni: 0.000111724
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPL53
Tdark
Novelty: 1.0076471
p_int: 0.999708868
p_ni: 0.000291132
Score: 0.99
Data Source: BioPlex,STRINGDB
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.999429762
p_ni: 0.000570238
Score: 0.999
Data Source: BioPlex,STRINGDB
RPL37
Tbio
Novelty: 0.03935854
p_int: 0.999404238
p_ni: 0.000595762
Data Source: BioPlex
MRPL42
Tbio
Novelty: 0.48241447
p_int: 0.999218769
p_ni: 0.000781231
Score: 0.996
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.998913018
p_ni: 0.001086982
Score: 0.999
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.998530476
p_ni: 0.001469521
p_wrong: 3e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.69

PubMed score by year
PubTator Score  8.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer