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Tbio
SLC52A3
Solute carrier family 52, riboflavin transporter, member 3

Protein Summary
Description
Transporter for riboflavin, which must be obtained as a nutrient via intestinal absorption (PubMed:20463145, PubMed:24264046, PubMed:22273710, PubMed:27702554). Riboflavin transport is Na(+)-independent at low pH but significantly reduced by Na(+) depletion under neutral pH conditions (PubMed:24264046). This gene encodes a riboflavin transporter protein that is strongly expressed in the intestine and likely plays a role in intestinal absorption of riboflavin. The protein is predicted to have eleven transmembrane domains and a cell surface localization signal in the C-terminus. Mutations at this locus have been associated with Brown-Vialetto-Van Laere syndrome and Fazio-Londe disease. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000217254
  • ENSP00000217254
  • ENSG00000101276
  • ENST00000381944
  • ENSP00000371370
  • ENST00000488495
  • ENSP00000494009
  • ENST00000632431
  • ENSP00000488723
  • ENST00000645534
  • ENSP00000494193

Symbol
  • C20orf54
  • RFT2
  • RFVT3
  • RFT2
  • BVVLS
  • RFVT3
  • hRFT2
  • BVVLS1
  • C20orf54
  • bA371L19.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
pathway
0.78
tissue sample
0.68
PubMedID
0.63
gene perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.69   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 90.69   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
DLEC1
Tbio
Novelty:  0.0300128
Score:  0.72
Data Source:  STRINGDB
PLCE1
Tbio
Family:  Enzyme
Novelty:  0.0070258
Score:  0.668
Data Source:  STRINGDB
FLAD1
Tbio
Family:  Enzyme
Novelty:  0.02230368
Score:  0.58
Data Source:  STRINGDB
RDH5
Tbio
Family:  Enzyme
Novelty:  0.0111079
Score:  0.575
Data Source:  STRINGDB
SLC35G2
Tdark
Family:  Transporter
Novelty:  0.57896683
Score:  0.55
Data Source:  STRINGDB
RFK
Tbio
Family:  Enzyme
Novelty:  0.00973729
Score:  0.546
Data Source:  STRINGDB
TMEM173
Tchem
Novelty:  0.0070581
Score:  0.536
Data Source:  STRINGDB
ATP1B2
Tclin
Family:  Transporter
Novelty:  0.02641193
Score:  0.506
Data Source:  STRINGDB
RAB37
Tbio
Family:  Enzyme
Novelty:  0.07133253
Score:  0.505
Data Source:  STRINGDB
ATP8A2
Tbio
Family:  Transporter
Novelty:  0.03876526
Score:  0.501
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B2 (riboflavin) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B2 (riboflavin) metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fat body mass
1
1
0
6.4
5.6
helping behavior measurement
1
1
1
5.4
glomerular filtration rate
1
1
1
4.1
creatinine measurement
1
1
1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fat body mass
0
6.4
5.6
helping behavior measurement
1
5.4
glomerular filtration rate
1
4.1
creatinine measurement
1
4.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 52 member 3
VGNC:9987
458028
Macaque
solute carrier family 52 member 3
715057
Mouse
MGI:1916948
69698
Rat
RGD:1304644
311536
Dog
solute carrier family 52 member 3
VGNC:46442
100856604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 52 member 3
Macaque
solute carrier family 52 member 3
Mouse
Rat
Dog
solute carrier family 52 member 3
Publication Statistics
PubMed Score 90.69
PubMed score by year
PubTator Score 56.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title