Tbio SLC52A3 Solute carrier family 52, riboflavin transporter, member 3

Protein Summary

Description

Transporter for riboflavin, which must be obtained as a nutrient via intestinal absorption (PubMed:20463145, PubMed:24264046, PubMed:22273710, PubMed:27702554). Riboflavin transport is Na(+)-independent at low pH but significantly reduced by Na(+) depletion under neutral pH conditions (PubMed:24264046). This gene encodes a riboflavin transporter protein that is strongly expressed in the intestine and likely plays a role in intestinal absorption of riboflavin. The protein is predicted to have eleven transmembrane domains and a cell surface localization signal in the C-terminus. Mutations at this locus have been associated with Brown-Vialetto-Van Laere syndrome and Fazio-Londe disease. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• Q9NQ40
• A0A2I6BQ49
• A8K6P1
• K0A6P4
• Q5W1A0
• Q5W1A1
• Q8NCL7
• Q96GD5

Gene Name

• SLC52A3

Ensembl ID

• ENST00000217254
• ENSP00000217254
• ENSG00000101276
• ENST00000381944
• ENSP00000371370
• ENST00000488495
• ENSP00000494009
• ENST00000632431
• ENSP00000488723
• ENST00000645534
• ENSP00000494193

Symbol

• C20orf54
• RFT2
• RFVT3
• RFT2
• BVVLS
• RFVT3
• hRFT2
• BVVLS1
• C20orf54
• bA371L19.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.81
pathway	0.78
tissue sample	0.68
PubMedID	0.63
gene perturbation	0.59

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Solute Carrier Family 52, Riboflavin Transporter, Member 3

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc52 Family Of Riboflavin Transporters / Solute Carrier Family 52, Riboflavin Transporter, Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.49   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 111.49   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0