SLC52A3
Solute carrier family 52, riboflavin transporter, member 3
Protein Summary
Transporter for riboflavin, which must be obtained as a nutrient via intestinal absorption (PubMed:20463145, PubMed:24264046, PubMed:22273710, PubMed:27702554). Riboflavin transport is Na(+)-independent at low pH but significantly reduced by Na(+) depletion under neutral pH conditions (PubMed:24264046). This gene encodes a riboflavin transporter protein that is strongly expressed in the intestine and likely plays a role in intestinal absorption of riboflavin. The protein is predicted to have eleven transmembrane domains and a cell surface localization signal in the C-terminus. Mutations at this locus have been associated with Brown-Vialetto-Van Laere syndrome and Fazio-Londe disease. [provided by RefSeq, Mar 2012]
- ENST00000217254
- ENSP00000217254
- ENSG00000101276
- ENST00000381944
- ENSP00000371370
- ENST00000488495
- ENSP00000494009
- ENST00000632431
- ENSP00000488723
- ENST00000645534
- ENSP00000494193
- C20orf54
- RFT2
- RFVT3
- RFT2
- BVVLS
- RFVT3
- hRFT2
- BVVLS1
- C20orf54
- bA371L19.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.81 | ||
pathway | 0.78 | ||
tissue sample | 0.68 | ||
PubMedID | 0.63 | ||
gene perturbation | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 90.69 (req: < 5)
Gene RIFs: 33 (req: <= 3)
Antibodies: 53 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 90.69 (req: >= 5)
Gene RIFs: 33 (req: > 3)
Antibodies: 53 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (29)
Nearest Tclin Targets
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of vitamins and cofactors | ||||
Reactome | Metabolism of water-soluble vitamins and cofactors | ||||
Reactome | Vitamin B2 (riboflavin) metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of vitamins and cofactors | ||||
Metabolism of water-soluble vitamins and cofactors | ||||
Vitamin B2 (riboflavin) metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (1)
Components (6)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
fat body mass | 1 | 1 | 0 | 6.4 | 5.6 | ||||
helping behavior measurement | 1 | 1 | 1 | 5.4 | |||||
glomerular filtration rate | 1 | 1 | 1 | 4.1 | |||||
creatinine measurement | 1 | 1 | 1 | 4.1 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
fat body mass | 0 | 6.4 | 5.6 | ||||
helping behavior measurement | 1 | 5.4 | |||||
glomerular filtration rate | 1 | 4.1 | |||||
creatinine measurement | 1 | 4.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier family 52 member 3 | VGNC:9987 | 458028 | |||||
Macaque | solute carrier family 52 member 3 | 715057 | ||||||
Mouse | MGI:1916948 | 69698 | ||||||
Rat | RGD:1304644 | 311536 | ||||||
Dog | solute carrier family 52 member 3 | VGNC:46442 | 100856604 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier family 52 member 3 | |||||
Macaque | solute carrier family 52 member 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 52 member 3 | |||||
Publication Statistics
PubMed Score 90.69
PubMed score by year
PubTator Score 56.50
PubTator score by year
Related Publications
Text Mined References (40)
GeneRif Annotations (33)
Items per page:
0 of 0
PMID | Year | Title |
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