Tbio SPINK5 Serine protease inhibitor Kazal-type 5

Protein Summary

Description

Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Uniprot Accession IDs

• Q9NQ38
• A8MYE8
• B7WPB7
• D6REN5
• O75770
• Q3LX95
• Q3LX96
• Q3LX97
• Q96PP2
• Q96PP3

Gene Name

• SPINK5

Ensembl ID

• ENST00000256084
• ENSP00000256084
• ENSG00000133710
• ENST00000359874
• ENSP00000352936
• ENST00000398454
• ENSP00000381472

Symbol

• NS
• NETS
• LEKTI
• LETKI
• VAKTI

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.66
biological term	0.63
biological process	0.62
small molecule perturbation	0.61
gene perturbation	0.58

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor Kazal-type 5

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor Kazal-type 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.81   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 242.81   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0