You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SPINK5
Serine protease inhibitor Kazal-type 5

Protein Summary
Description
Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may exhibit unique activities and specificities. These proteins may play a role in skin and hair morphogenesis, as well as anti-inflammatory and antimicrobial protection of mucous epithelia. Mutations in this gene may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. This gene is present in a gene cluster on chromosome 5. Alternative splicing results i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256084
  • ENSP00000256084
  • ENSG00000133710
  • ENST00000359874
  • ENSP00000352936
  • ENST00000398454
  • ENSP00000381472

Symbol
  • NS
  • NETS
  • LEKTI
  • LETKI
  • VAKTI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.66
biological term
0.63
biological process
0.62
small molecule perturbation
0.61
gene perturbation
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.16   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 201.16   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
serine peptidase inhibitor, Kazal type 5
709424
Mouse
MGI:1919682
72432
Dog
serine peptidase inhibitor, Kazal type 5
VGNC:46745
478055
Horse
serine peptidase inhibitor, Kazal type 5
VGNC:23523
100071873
Cow
serine peptidase inhibitor, Kazal type 5
VGNC:35220
526637
Species
Name
OMA
EggNOG
Inparanoid
Macaque
serine peptidase inhibitor, Kazal type 5
Mouse
Dog
serine peptidase inhibitor, Kazal type 5
Horse
serine peptidase inhibitor, Kazal type 5
Cow
serine peptidase inhibitor, Kazal type 5
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NQ38-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Gene Ontology Terms (22)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (69)
1 – 10 of 69
TFG
Tbio
Novelty: 0.00320616
p_int: 0.99999984
p_ni: 1.25e-7
p_wrong: 3.5e-8
Score: 0.403
Data Source: BioPlex,STRINGDB
BTC
Tbio
Novelty: 0.00673076
p_int: 0.77990167
p_ni: 0.00007023
p_wrong: 0.2200281
Data Source: BioPlex
KLK5
Tchem
Family: Enzyme
Novelty: 0.00835407
Score: 0.972
Data Source: Reactome,STRINGDB
CELA2A
Tbio
Family: Enzyme
Novelty: 0.14098356
Score: 0.905
Data Source: STRINGDB
KLK14
Tchem
Family: Enzyme
Novelty: 0.02007434
Score: 0.836
Data Source: STRINGDB
FLG
Tbio
Novelty: 0.00072986
Score: 0.819
Data Source: STRINGDB
ST14
Tchem
Novelty: 0.00278331
Score: 0.752
Data Source: STRINGDB
SPINK6
Tbio
Family: Enzyme
Novelty: 0.11687263
Score: 0.749
Data Source: STRINGDB
KLK7
Tchem
Family: Enzyme
Novelty: 0.00757766
Score: 0.733
Data Source: STRINGDB
SPINK2
Tdark
Family: Enzyme
Novelty: 0.06832697
Score: 0.706
Data Source: STRINGDB
Publication Statistics
PubMed Score  201.16

PubMed score by year
PubTator Score  129.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: