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Tbio
ASCL3
Achaete-scute homolog 3

Protein Summary
Description
Transcriptional repressor. Inhibits myogenesis (By similarity). Basic helix-loop-helix transcription factors, such as ASCL3, are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al., 2004 [PubMed 15475265]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000531618
  • ENSP00000435770
  • ENSG00000176009

Symbol
  • BHLHA42
  • HASH3
  • SGN1
  • SGN1
  • HASH3
  • bHLHa42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
cell type or tissue
0.76
tissue sample
0.56
gene perturbation
0.48
disease perturbation
0.43


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.07   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.07   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
achaete-scute family bHLH transcription factor 3
705072
Mouse
MGI:1928820
56787
Dog
achaete-scute family bHLH transcription factor 3
VGNC:38175
100686513
Opossum
achaete-scute family bHLH transcription factor 3
100029514
Platypus
achaete-scute family bHLH transcription factor 3
100078656
Species
Name
OMA
EggNOG
Inparanoid
Macaque
achaete-scute family bHLH transcription factor 3
Mouse
Dog
achaete-scute family bHLH transcription factor 3
Opossum
achaete-scute family bHLH transcription factor 3
Platypus
achaete-scute family bHLH transcription factor 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NQ33-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (27)
1 – 10 of 27
TCF3
Tbio
Family: TF
Novelty: 0.00112675
Score: 0.861
Data Source: STRINGDB
ID1
Tbio
Family: TF
Novelty: 0.00151069
Score: 0.842
Data Source: STRINGDB
MYOD1
Tbio
Family: TF
Novelty: 0.00053412
Score: 0.737
Data Source: STRINGDB
NEUROD4
Tbio
Family: TF
Novelty: 0.03787483
Score: 0.691
Data Source: STRINGDB
ACSL6
Tbio
Family: Enzyme
Novelty: 0.0100317
Score: 0.614
Data Source: STRINGDB
FOXN4
Tbio
Family: TF
Novelty: 0.04762528
Score: 0.584
Data Source: STRINGDB
ACBD6
Tbio
Novelty: 0.3555227
Score: 0.564
Data Source: STRINGDB
PET100
Tbio
Novelty: 0.17104943
Score: 0.556
Data Source: STRINGDB
ACSL4
Tbio
Family: Enzyme
Novelty: 0.0072645
Score: 0.551
Data Source: STRINGDB
ACSL3
Tbio
Family: Enzyme
Novelty: 0.01772336
Score: 0.539
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.07

PubMed score by year
PubTator Score  16.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer