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Tclin
SLAMF7
SLAM family member 7

Protein Summary
Description
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (B ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359331
  • ENSP00000352281
  • ENSG00000026751
  • ENST00000368042
  • ENSP00000357021
  • ENST00000368043
  • ENSP00000357022
  • ENST00000441662
  • ENSP00000405605
  • ENST00000444090
  • ENSP00000416592
  • ENST00000458602
  • ENSP00000409965

Symbol
  • CS1
  • 19A
  • CS1
  • CD319
  • CRACC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell type or tissue
0.61
gene perturbation
0.53
tissue sample
0.5
microRNA
0.49


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.88   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 457   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.88   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 457   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
elotuzumab
no chemical structure image available
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
2
3
92.5
lymphocyte percentage of leukocytes
2
3
3
85.8
2
3
0
1.1
78.3
neutrophil percentage of leukocytes
1
1
1
40.7
serum IgM measurement
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
92.5
lymphocyte percentage of leukocytes
3
85.8
0
1.1
78.3
neutrophil percentage of leukocytes
1
40.7
serum IgM measurement
1
30.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SLAM family member 7
VGNC:1551
746961
Macaque
SLAM family member 7
719781
Mouse
MGI:1922595
75345
Rat
RGD:1560190
364049
Dog
SLAM family member 7
VGNC:46208
609992
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SLAM family member 7
Macaque
SLAM family member 7
Mouse
Rat
Dog
SLAM family member 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NQ25-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (51)
1 – 10 of 51
TBC1D23
Tbio
Novelty:  0.18566729
p_int:  0.999999992
p_ni:  8e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
PTCD2
Tdark
Novelty:  0.23529342
p_int:  0.995133836
p_ni:  0.004866164
Score:  0.205
Data Source:  BioPlex,STRINGDB
HUS1
Tbio
Novelty:  0.00837493
p_int:  0.963826041
p_ni:  0.00771189
p_wrong:  0.028462069
Score:  0.167
Data Source:  BioPlex,STRINGDB
NAGPA
Tbio
Family:  Enzyme
Novelty:  0.03136768
p_int:  0.952203956
p_ni:  0.047796044
Score:  0.295
Data Source:  BioPlex,STRINGDB
FBXO2
Tbio
Novelty:  0.01578361
p_int:  0.863098435
p_ni:  0.136901565
p_wrong:  1e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
LGALS1
Tchem
Novelty:  0.00106509
p_int:  0.861758763
p_ni:  0.138150553
p_wrong:  0.000090684
Score:  0.337
Data Source:  BioPlex,STRINGDB
YIF1A
Tdark
Novelty:  0.07180782
p_int:  0.847893029
p_ni:  0.152106971
Score:  0.209
Data Source:  BioPlex,STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
p_int:  0.799791588
p_ni:  0.200208412
Score:  0.187
Data Source:  BioPlex,STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
p_int:  0.790673738
p_ni:  0.209326262
Score:  0.187
Data Source:  BioPlex,STRINGDB
APBB1
Tbio
Novelty:  0.00630564
p_int:  0.777526147
p_ni:  0.220759073
p_wrong:  0.001714779
Score:  0.205
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  118.88

PubMed score by year
PubTator Score  570.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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