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Tbio
ATP13A2
Cation-transporting ATPase 13A2

Protein Summary
Description
ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity (PubMed:22186024). Required for a proper lysosomal and mitochondrial maintenance (PubMed:22296644, PubMed:28137957). This gene encodes a member of the P5 subfamily of ATPases which transports inorganic cations as well as other substrates. Mutations in this gene are associated with Kufor-Rakeb syndrome (KRS), also referred to as Parkinson disease 9. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326735
  • ENSP00000327214
  • ENSG00000159363
  • ENST00000341676
  • ENSP00000341115
  • ENST00000452699
  • ENSP00000413307

Symbol
  • PARK9
  • CLN12
  • KRPPD
  • PARK9
  • SPG78
  • HSA9947
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
protein domain
0.92
histone modification site profile
0.82
kinase perturbation
0.76
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.9   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.9   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (114)
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.999927543
p_ni:  0.000072456
p_wrong:  2e-9
Score:  0.15
Data Source:  BioPlex,STRINGDB
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.999695385
p_ni:  0.000304615
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.999649233
p_ni:  0.000350767
Data Source:  BioPlex
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.998632555
p_ni:  0.001367445
Data Source:  BioPlex
PCDHA3
Tdark
Novelty:  0.8622898
p_int:  0.997856619
p_ni:  0.002143381
Data Source:  BioPlex
PCDHGB2
Tdark
Novelty:  1.16587709
p_int:  0.997388849
p_ni:  0.002611151
Data Source:  BioPlex
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.99663779
p_ni:  0.00336221
Data Source:  BioPlex
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.99456931
p_ni:  0.00543069
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.98307024
p_ni:  0.01692976
Data Source:  BioPlex
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.978752388
p_ni:  0.021247535
p_wrong:  7.7e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Ion transport by P-type ATPases
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Ion transport by P-type ATPases
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (49)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
8
20
39
95.2
BMI-adjusted hip circumference
3
19
21
94.7
body height
5
3
7
94.6
waist circumference
1
8
8
81.5
hemoglobin measurement
2
2
2
79.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
39
95.2
BMI-adjusted hip circumference
21
94.7
body height
7
94.6
waist circumference
8
81.5
hemoglobin measurement
2
79.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATPase cation transporting 13A2
VGNC:448
456525
Macaque
ATPase 13A2
699678
Mouse
MGI:1922022
74772
Rat
RGD:1307977
362645
Dog
ATPase cation transporting 13A2
VGNC:38242
100686975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATPase cation transporting 13A2
Macaque
ATPase 13A2
Mouse
Rat
Dog
ATPase cation transporting 13A2
Publication Statistics
PubMed Score 178.90
PubMed score by year
PubTator Score 111.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title