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Tbio
SEMA4B
Semaphorin-4B

Protein Summary
Description
Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379122
  • ENSP00000368417
  • ENSG00000185033

Symbol
  • KIAA1745
  • SEMAC
  • SemC
  • SEMAC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor binding site profile
0.83
histone modification site profile
0.81
cell type or tissue
0.74
transcription factor
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.93   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.93   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
7.3
79.2
urate measurement
3
3
3
77.8
1
1
0
1.3
63.1
serum gamma-glutamyl transferase measurement
2
1
2
52
comparative body size at age 10, self-reported
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
7.3
79.2
urate measurement
3
77.8
0
1.3
63.1
serum gamma-glutamyl transferase measurement
2
52
comparative body size at age 10, self-reported
1
47.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
semaphorin 4B
VGNC:6588
453646
Macaque
semaphorin 4B
708168
Mouse
MGI:107559
20352
Rat
RGD:1307872
293042
Dog
semaphorin 4B
VGNC:45995
488741
Species
Name
OMA
EggNOG
Inparanoid
Chimp
semaphorin 4B
Macaque
semaphorin 4B
Mouse
Rat
Dog
semaphorin 4B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NPR2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (87)
1 – 10 of 87
AEN
Tbio
Family:  Enzyme
Novelty:  0.04318322
p_int:  0.999807911
p_ni:  0.000091777
p_wrong:  0.000100312
Score:  0.689
Data Source:  BioPlex,STRINGDB
SEMA4A
Tbio
Novelty:  0.01062916
p_int:  0.993488178
p_ni:  0.006506451
p_wrong:  0.000005371
Data Source:  BioPlex
PDCD2
Tbio
Novelty:  0.05054811
p_int:  0.90636668
p_ni:  0.093627793
p_wrong:  0.000005527
Data Source:  BioPlex
PLXNB1
Tbio
Novelty:  0.01073808
Score:  0.86
Data Source:  STRINGDB
NRP2
Tbio
Novelty:  0.00764179
Score:  0.848
Data Source:  STRINGDB
NRP1
Tchem
Novelty:  0.00153628
Score:  0.847
Data Source:  STRINGDB
PLXNB2
Tbio
Novelty:  0.01925055
Score:  0.808
Data Source:  STRINGDB
PLXNB3
Tbio
Novelty:  0.02948198
Score:  0.804
Data Source:  STRINGDB
EFNA4
Tbio
Novelty:  0.03628159
Score:  0.799
Data Source:  STRINGDB
EFNA1
Tbio
Family:  Kinase
Novelty:  0.00732252
Score:  0.799
Data Source:  STRINGDB
Publication Statistics
PubMed Score  60.93

PubMed score by year
PubTator Score  21.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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