Tbio NLRC4 NLR family CARD domain-containing protein 4

Protein Summary

Description

Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity). This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• Q9NPP4
• A8K9F8
• B2RBQ3
• B3KTF0
• D6W580
• Q96J81
• Q96J82
• Q96J83

Gene Name

• NLRC4

Ensembl ID

• ENST00000342905
• ENSP00000339666
• ENSG00000091106
• ENST00000360906
• ENSP00000354159
• ENST00000402280
• ENSP00000385428
• ENST00000404025
• ENSP00000385090

Symbol

• CARD12
• CLAN
• CLAN1
• IPAF
• CLAN
• IPAF
• AIFEC
• CLAN1
• CLANA
• CLANB
• CLANC
• CLAND
• FCAS4
• CARD12
• CLR2.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
biological process	0.97
tissue sample	0.77
protein domain	0.58
PubMedID	0.58

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.84   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 303   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.84   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
interleukin 18 measurement	EFO_0004581	2	2	2		97.4
sex hormone-binding globulin measurement	EFO_0004696	2	1	2		83.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
interleukin 18 measurement	EFO_0004581	2		97.4
sex hormone-binding globulin measurement	EFO_0004696	2		83.8

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Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NLR family CARD domain containing 4	VGNC:8253	459135
Macaque	NLR family CARD domain containing 4		706378
Mouse	NLR family, CARD domain containing 4	MGI:3036243	268973
Rat	NLR family, CARD domain containing 4	RGD:1309831	298784
Horse	NLR family CARD domain containing 4	VGNC:20765	100070605

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NLR family CARD domain containing 4
Macaque	NLR family CARD domain containing 4
Mouse	NLR family, CARD domain containing 4
Rat	NLR family, CARD domain containing 4
Horse	NLR family CARD domain containing 4

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NPP4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (36)

Reactome (11)

KEGG (3)

PathwayCommons (1)

WikiPathways (21)

Gene expression (Transcription) (R-HSA-74160)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Inflammasomes	20 targets	R-HSA-622312
Reactome	Innate Immune System	1188 targets	R-HSA-168249

Name	Explore in Pharos	Explore in Source
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Immune System	2246 targets	R-HSA-168256
Inflammasomes	20 targets	R-HSA-622312
Innate Immune System	1188 targets	R-HSA-168249

Gene Ontology Terms (19)

Functions (4)

Components (2)

Processes (13)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
ATP binding	Inferred from Direct Assay (IDA)	HGNC
protein homodimerization activity	Inferred from Direct Assay (IDA)	HGNC
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
magnesium ion binding	Traceable Author Statement (TAS)	HGNC

Protein-Protein Interactions (114)

Explore Interacting Targets

1 – 10 of 114

• See Interactions on String-DB

CASP1

Tchem

Family: Enzyme

Novelty: 0.00034643

Score: 0.997

Data Source: Reactome,STRINGDB

NLRP3

Tchem

Novelty: 0.00043957

Score: 0.98

Data Source: STRINGDB

PYCARD

Tbio

Novelty: 0.00719985

Score: 0.977

Data Source: STRINGDB

NLRP1

Tbio

Novelty: 0.00441627

Score: 0.977

Data Source: STRINGDB

NAIP

Tbio

Novelty: 0.00400896

Score: 0.975

Data Source: STRINGDB

AIM2

Tbio

Novelty: 0.00360474

Score: 0.964

Data Source: STRINGDB

IL18

Tbio

Novelty: 0.00022844

Score: 0.962

Data Source: STRINGDB

IL1B

Tclin

Novelty: 0.0000308

Score: 0.94

Data Source: STRINGDB

CASP5

Tchem

Family: Enzyme

Novelty: 0.00734661

Score: 0.931

Data Source: STRINGDB

TP53

Tchem

Family: TF

Novelty: 0.00001907

Score: 0.917

Data Source: STRINGDB

Publication Statistics

PubMed Score  308.84

PubMed score by year

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PubTator Score  94.95

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Apoptosis
ATP-binding
Complete proteome
Cytoplasm
Disease mutation
Immunity
Inflammatory response
Innate immunity

GWAS Trait Find Similar Targets

interleukin 18 measurement
sex hormone-binding globulin measurement

MGI Phenotype Find Similar Targets

cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
skeleton phenotype