NLRC4
NLR family CARD domain-containing protein 4
Protein Summary
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity). This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
- ENST00000342905
- ENSP00000339666
- ENSG00000091106
- ENST00000360906
- ENSP00000354159
- ENST00000402280
- ENSP00000385428
- ENST00000404025
- ENSP00000385090
- CARD12
- CLAN
- CLAN1
- IPAF
- CLAN
- IPAF
- AIFEC
- CLAN1
- CLANA
- CLANB
- CLANC
- CLAND
- FCAS4
- CARD12
- CLR2.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
biological process | 0.97 | ||
tissue sample | 0.77 | ||
protein domain | 0.58 | ||
PubMedID | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 340.69 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 303 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 340.69 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 303 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (114)
Nearest Tclin Targets
Pathways (36)
Reactome (11)
KEGG (3)
PathwayCommons (1)
WikiPathways (21)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | Immune System | ||||
Reactome | Inflammasomes | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Immune System | ||||
Inflammasomes | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (19)
Functions (4)
Components (2)
Processes (13)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Traceable Author Statement (TAS) | HGNC | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
interleukin 18 measurement | 2 | 2 | 2 | 95.1 | |||||
testosterone measurement | 1 | 2 | 2 | 82.2 | |||||
sex hormone-binding globulin measurement | 4 | 2 | 4 | 74 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 44.2 | |||||
reticulocyte count | 4 | 1 | 4 | 17.7 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
interleukin 18 measurement | 2 | 95.1 | |||||
testosterone measurement | 2 | 82.2 | |||||
sex hormone-binding globulin measurement | 4 | 74 | |||||
apolipoprotein A 1 measurement | 1 | 44.2 | |||||
reticulocyte count | 4 | 17.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | NLR family CARD domain containing 4 | VGNC:8253 | 459135 | |||||
Macaque | NLR family CARD domain containing 4 | 706378 | ||||||
Mouse | MGI:3036243 | 268973 | ||||||
Rat | RGD:1309831 | 298784 | ||||||
Horse | NLR family CARD domain containing 4 | VGNC:20765 | 100070605 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | NLR family CARD domain containing 4 | |||||
Macaque | NLR family CARD domain containing 4 | |||||
Mouse | ||||||
Rat | ||||||
Horse | NLR family CARD domain containing 4 | |||||
Publication Statistics
PubMed Score 340.69
PubMed score by year
PubTator Score 94.95
PubTator score by year
Related Publications
Text Mined References (46)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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