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Tbio
NLRC4
NLR family CARD domain-containing protein 4

Protein Summary
Description
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity). This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342905
  • ENSP00000339666
  • ENSG00000091106
  • ENST00000360906
  • ENSP00000354159
  • ENST00000402280
  • ENSP00000385428
  • ENST00000404025
  • ENSP00000385090

Symbol
  • CARD12
  • CLAN
  • CLAN1
  • IPAF
  • CLAN
  • IPAF
  • AIFEC
  • CLAN1
  • CLANA
  • CLANB
  • CLANC
  • CLAND
  • FCAS4
  • CARD12
  • CLR2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
biological process
0.97
tissue sample
0.77
protein domain
0.58
PubMedID
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.84   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 303   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.84   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 303   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
2
2
2
97.4
sex hormone-binding globulin measurement
2
1
2
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin 18 measurement
2
97.4
sex hormone-binding globulin measurement
2
83.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NLR family CARD domain containing 4
VGNC:8253
459135
Macaque
NLR family CARD domain containing 4
706378
Mouse
MGI:3036243
268973
Rat
RGD:1309831
298784
Horse
NLR family CARD domain containing 4
VGNC:20765
100070605
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NLR family CARD domain containing 4
Macaque
NLR family CARD domain containing 4
Mouse
Rat
Horse
NLR family CARD domain containing 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NPP4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (36)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Reactome
Inflammasomes
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Inflammasomes
Innate Immune System
Protein-Protein Interactions (114)
1 – 10 of 114
CASP1
Tchem
Family: Enzyme
Novelty: 0.00034643
Score: 0.997
Data Source: Reactome,STRINGDB
NLRP3
Tchem
Novelty: 0.00043957
Score: 0.98
Data Source: STRINGDB
PYCARD
Tbio
Novelty: 0.00719985
Score: 0.977
Data Source: STRINGDB
NLRP1
Tbio
Novelty: 0.00441627
Score: 0.977
Data Source: STRINGDB
NAIP
Tbio
Novelty: 0.00400896
Score: 0.975
Data Source: STRINGDB
AIM2
Tbio
Novelty: 0.00360474
Score: 0.964
Data Source: STRINGDB
IL18
Tbio
Novelty: 0.00022844
Score: 0.962
Data Source: STRINGDB
IL1B
Tclin
Novelty: 0.0000308
Score: 0.94
Data Source: STRINGDB
CASP5
Tchem
Family: Enzyme
Novelty: 0.00734661
Score: 0.931
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  308.84

PubMed score by year
PubTator Score  94.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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