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Tbio
TIMMDC1
Complex I assembly factor TIMMDC1, mitochondrial

Protein Summary
Description
Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000494664
  • ENSP00000418803
  • ENSG00000113845

Symbol
  • C3orf1
  • C3orf1
  • MC1DN31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
tissue sample
0.68
transcription factor binding site profile
0.63
phenotype
0.61
tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.09   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.09   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
NDUFAF1
Tclin
Novelty:  0.05630549
p_int:  0.996794126
p_ni:  0.003205874
Score:  0.992
Data Source:  BioPlex,STRINGDB
ECSIT
Tbio
Novelty:  0.04690184
p_int:  0.903911607
p_ni:  0.096088393
Score:  0.993
Data Source:  BioPlex,STRINGDB
ACAD9
Tbio
Family:  Enzyme
Novelty:  0.03238308
p_int:  0.902794161
p_ni:  0.097205839
Score:  0.989
Data Source:  BioPlex,STRINGDB
NDUFC2
Tclin
Family:  Enzyme
Novelty:  0.08387385
p_int:  0.877659835
p_ni:  0.122336778
p_wrong:  0.000003386
Score:  0.985
Data Source:  BioPlex,STRINGDB
ARL5B
Tbio
Family:  Enzyme
Novelty:  0.03703395
p_int:  0.875744071
p_ni:  0.095373144
p_wrong:  0.028882784
Score:  0.204
Data Source:  BioPlex,STRINGDB
TMEM126B
Tbio
Novelty:  0.21278172
Score:  0.996
Data Source:  STRINGDB
NDUFAF4
Tclin
Family:  Enzyme
Novelty:  0.10799507
Score:  0.983
Data Source:  Reactome,STRINGDB
NDUFB6
Tclin
Family:  Enzyme
Novelty:  0.075245
Score:  0.983
Data Source:  STRINGDB
NDUFA8
Tclin
Family:  Enzyme
Novelty:  0.05772867
Score:  0.981
Data Source:  STRINGDB
NDUFAF3
Tclin
Family:  Enzyme
Novelty:  0.00063584
Score:  0.981
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.2
92.6
4
4
0
1.2
84.3
primary biliary cirrhosis
4
3
0
1.4
79.8
2
2
0
1.3
64.3
Thyroid preparation use measurement
1
1
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
92.6
0
1.2
84.3
primary biliary cirrhosis
0
1.4
79.8
0
1.3
64.3
Thyroid preparation use measurement
1
56.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane domain containing 1
VGNC:2605
460606
Macaque
translocase of inner mitochondrial membrane domain containing 1
712414
Mouse
MGI:1922139
76916
Rat
RGD:1359380
303922
Dog
translocase of inner mitochondrial membrane domain containing 1
VGNC:49626
487994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocase of inner mitochondrial membrane domain containing 1
Macaque
translocase of inner mitochondrial membrane domain containing 1
Mouse
Rat
Dog
translocase of inner mitochondrial membrane domain containing 1
Publication Statistics
PubMed Score 10.09
PubMed score by year
PubTator Score 6.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title