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Tdark
NXT2
NTF2-related export protein 2

Protein Summary
Description
Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export. The protein encoded by this gene contains a nuclear transport factor 2 (NTF2) domain, which plays an important role in the trafficking of macromolecules, ions, and small molecules between the cytoplasm and nucleus. This protein may also have a role in mRNA nuclear export. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218004
  • ENSP00000218004
  • ENSG00000101888
  • ENST00000372103
  • ENSP00000361175
  • ENST00000372106
  • ENSP00000361178
  • ENST00000372107
  • ENSP00000361179

Symbol
  • P15-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
microRNA
0.69
kinase perturbation
0.6
tissue sample
0.59
cell line
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.3   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 34   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.3   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 34   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (75)
1 – 10 of 75
INPP4A
Tbio
Family:  Enzyme
Novelty:  0.03714963
p_int:  1
Score:  0.379
Data Source:  BioPlex,STRINGDB
NXF1
Tbio
Novelty:  0.00642439
p_int:  0.999999998
p_ni:  2e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
PTAR1
Tdark
Family:  Enzyme
Novelty:  0.37120559
p_int:  0.999997819
p_ni:  0.000002179
p_wrong:  2e-9
Score:  0.309
Data Source:  BioPlex,STRINGDB
RGS8
Tchem
Novelty:  0.03314557
p_int:  0.999996433
p_ni:  0.000001053
p_wrong:  0.000002514
Score:  0.379
Data Source:  BioPlex,STRINGDB
NXF2
Tbio
Novelty:  0.04733504
p_int:  0.999822278
p_ni:  0.000020989
p_wrong:  0.000156733
Score:  0.997
Data Source:  BioPlex,STRINGDB
NXF3
Tbio
Novelty:  0.16514217
p_int:  0.99974781
p_ni:  0.00006404
p_wrong:  0.000188151
Score:  0.993
Data Source:  BioPlex,STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
p_int:  0.99973326
p_ni:  0.00026674
Score:  0.165
Data Source:  BioPlex,STRINGDB
NXF5
Tbio
Novelty:  0.18468434
Score:  0.983
Data Source:  STRINGDB
NUP98
Tbio
Family:  Enzyme
Novelty:  0.00401452
Score:  0.924
Data Source:  STRINGDB
NUTF2
Tbio
Novelty:  0.00334688
Score:  0.818
Data Source:  STRINGDB
Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Ribosome biogenesis in eukaryotes
KEGG
mRNA surveillance pathway
KEGG
RNA transport
KEGG
Influenza A
Name
Explore in Pharos
Explore in Source
Ribosome biogenesis in eukaryotes
mRNA surveillance pathway
RNA transport
Influenza A
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear transport factor 2 like export factor 2
VGNC:14704
473728
Macaque
nuclear transport factor 2 like export factor 2
704593
Mouse
MGI:2147914
237082
Rat
RGD:1560204
315352
Dog
nuclear transport factor 2 like export factor 2
VGNC:44080
612945
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear transport factor 2 like export factor 2
Macaque
nuclear transport factor 2 like export factor 2
Mouse
Rat
Dog
nuclear transport factor 2 like export factor 2
Publication Statistics
PubMed Score 24.30
PubMed score by year
PubTator Score 5.31
PubTator score by year