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Tbio
MED4
Mediator of RNA polymerase II transcription subunit 4

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258648
  • ENSP00000258648
  • ENSG00000136146
  • ENST00000378586
  • ENSP00000367849

Symbol
  • ARC36
  • DRIP36
  • VDRIP
  • ARC36
  • VDRIP
  • DRIP36
  • TRAP36
  • HSPC126
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
kinase perturbation
0.98
transcription factor binding site profile
0.94
protein complex
0.78
hub protein
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.21   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.21   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
0
5.9
13.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
0
5.9
13.1
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 4
VGNC:5075
452713
Macaque
mediator complex subunit 4
704644
Mouse
MGI:1914631
67381
Rat
RGD:1306671
306030
Dog
mediator complex subunit 4
VGNC:43139
476917
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 4
Macaque
mediator complex subunit 4
Mouse
Rat
Dog
mediator complex subunit 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NPJ6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (137)
1 – 10 of 137
MED26
Tbio
Family: Enzyme
Novelty: 0.05663538
p_int: 0.999999715
p_ni: 2.85e-7
Score: 0.972
Data Source: BioPlex,STRINGDB
CCDC14
Tdark
Novelty: 0.62617082
p_int: 0.999999329
p_ni: 6.56e-7
p_wrong: 1.5e-8
Score: 0.168
Data Source: BioPlex,STRINGDB
MED19
Tbio
Family: Enzyme
Novelty: 0.03926689
p_int: 0.999999281
p_ni: 7.18e-7
p_wrong: 2e-9
Score: 0.997
Data Source: BioPlex,STRINGDB
MED12L
Tdark
Family: Enzyme
Novelty: 0.09658419
p_int: 0.999999261
p_ni: 7.38e-7
Score: 0.83
Data Source: BioPlex,STRINGDB
MED17
Tbio
Family: Enzyme
Novelty: 0.02984503
p_int: 0.999998995
p_ni: 0.000001006
Score: 0.998
Data Source: BioPlex,STRINGDB
MED14
Tbio
Family: Enzyme
Novelty: 0.01741917
p_int: 0.999998532
p_ni: 0.000001468
Score: 0.996
Data Source: BioPlex,STRINGDB
MED24
Tbio
Family: Enzyme
Novelty: 0.05466084
p_int: 0.999998446
p_ni: 0.000001555
Score: 0.994
Data Source: BioPlex,STRINGDB
MED6
Tbio
Family: Enzyme
Novelty: 0.05215086
p_int: 0.999998433
p_ni: 0.000001567
Score: 0.997
Data Source: BioPlex,STRINGDB
MED13
Tbio
Family: Enzyme
Novelty: 0.02090708
p_int: 0.999998082
p_ni: 0.000001918
Score: 0.99
Data Source: BioPlex,STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
p_int: 0.999998024
p_ni: 0.000001976
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  82.21

PubMed score by year
PubTator Score  40.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer