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Tbio
PNRC2
Proline-rich nuclear receptor coactivator 2

Protein Summary
Description
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334351
  • ENSP00000334840
  • ENSG00000189266
  • ENST00000374468
  • ENSP00000363592
  • ENST00000647887
  • ENSP00000497590
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor binding site profile
0.87
histone modification site profile
0.82
transcription factor perturbation
0.74
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (160)
DCP1A
Tbio
Novelty:  0.02038933
Score:  0.997
Data Source:  STRINGDB
UPF1
Tbio
Novelty:  0.00311006
Score:  0.995
Data Source:  STRINGDB
SMG7
Tbio
Novelty:  0.03394393
Score:  0.976
Data Source:  STRINGDB
SMG5
Tbio
Novelty:  0.04143189
Score:  0.972
Data Source:  STRINGDB
SMG6
Tbio
Family:  Enzyme
Novelty:  0.0217417
Score:  0.971
Data Source:  STRINGDB
SMG8
Tdark
Novelty:  0.18080965
Score:  0.968
Data Source:  STRINGDB
SMG9
Tbio
Novelty:  0.03940774
Score:  0.967
Data Source:  STRINGDB
UPF2
Tbio
Novelty:  0.01064562
Score:  0.963
Data Source:  STRINGDB
SMG1
Tchem
Family:  Kinase
Novelty:  0.00854339
Score:  0.959
Data Source:  STRINGDB
UPF3A
Tbio
Novelty:  0.01431609
Score:  0.954
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome
Nonsense-Mediated Decay (NMD)
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
91.9
eosinophil percentage of leukocytes
2
2
2
85.5
lymphocyte count
1
1
1
59
eosinophil percentage of granulocytes
1
1
1
35
red blood cell distribution width
1
1
1
17.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
91.9
eosinophil percentage of leukocytes
2
85.5
lymphocyte count
1
59
eosinophil percentage of granulocytes
1
35
red blood cell distribution width
1
17.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:106512
52830
Rat
RGD:1642418
100125373
Cow
proline rich nuclear receptor coactivator 2
VGNC:33099
767836
Pig
proline rich nuclear receptor coactivator 2
100625012
Chicken
proline rich nuclear receptor coactivator 2
CGNC:51060
419688
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
proline rich nuclear receptor coactivator 2
Pig
proline rich nuclear receptor coactivator 2
Chicken
proline rich nuclear receptor coactivator 2
Publication Statistics
PubMed Score 12.38
PubMed score by year
PubTator Score 6.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title