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Tbio
PNRC2
Proline-rich nuclear receptor coactivator 2

Protein Summary
Description
Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334351
  • ENSP00000334840
  • ENSG00000189266
  • ENST00000374468
  • ENSP00000363592
  • ENST00000647887
  • ENSP00000497590
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor binding site profile
0.87
histone modification site profile
0.82
transcription factor perturbation
0.74
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.38   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.38   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome
Nonsense-Mediated Decay (NMD)
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Gene Ontology Terms (7)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (160)
1 – 10 of 160
DCP1A
Tbio
Novelty: 0.02038933
Score: 0.997
Data Source: STRINGDB
UPF1
Tbio
Novelty: 0.00311006
Score: 0.995
Data Source: STRINGDB
SMG7
Tbio
Novelty: 0.03394393
Score: 0.976
Data Source: STRINGDB
SMG5
Tbio
Novelty: 0.04143189
Score: 0.972
Data Source: STRINGDB
SMG6
Tbio
Family: Enzyme
Novelty: 0.0217417
Score: 0.971
Data Source: STRINGDB
SMG8
Tdark
Novelty: 0.18080965
Score: 0.968
Data Source: STRINGDB
SMG9
Tbio
Novelty: 0.03940774
Score: 0.967
Data Source: STRINGDB
UPF2
Tbio
Novelty: 0.01064562
Score: 0.963
Data Source: STRINGDB
SMG1
Tchem
Family: Kinase
Novelty: 0.00854339
Score: 0.959
Data Source: STRINGDB
UPF3A
Tbio
Novelty: 0.01431609
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.38

PubMed score by year
PubTator Score  6.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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