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Tbio
KCNJ16
Inward rectifier potassium channel 16

Protein Summary
Description
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201). Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which tends to allow potassium to flow into rather than out of a cell, can f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283936
  • ENSP00000283936
  • ENSG00000153822
  • ENST00000392670
  • ENSP00000376438
  • ENST00000392671
  • ENSP00000376439
  • ENST00000589377
  • ENSP00000465967
  • ENST00000615244
  • ENSP00000479817

Symbol
  • BIR9
  • KIR5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
virus perturbation
0.76
gene perturbation
0.72
protein domain
0.58
cell line
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.01   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.01   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (59)
GNB1
Tbio
Novelty:  0.02477955
Score:  0.955
Data Source:  Reactome,STRINGDB
KCNJ10
Tbio
Family:  IC
Novelty:  0.00273462
Score:  0.95
Data Source:  Reactome,STRINGDB
KCNJ15
Tbio
Family:  IC
Novelty:  0.03299706
Score:  0.947
Data Source:  Reactome,STRINGDB
KCNJ2
Tchem
Family:  IC
Novelty:  0.00290395
Score:  0.942
Data Source:  Reactome,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.929
Data Source:  Reactome,STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.929
Data Source:  Reactome,STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.908
Data Source:  STRINGDB
GABBR2
Tclin
Family:  GPCR
Novelty:  0.00739771
Score:  0.904
Data Source:  Reactome,STRINGDB
GNG7
Tbio
Novelty:  0.08478455
Score:  0.902
Data Source:  STRINGDB
GNG3
Tbio
Novelty:  0.16941216
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Activation of G protein gated Potassium channels (R-HSA-1296041)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
G protein gated Potassium channels
Reactome
GABA B receptor activation
Reactome
GABA receptor activation
Name
Explore in Pharos
Explore in Source
Activation of G protein gated Potassium channels
Activation of GABAB receptors
G protein gated Potassium channels
GABA B receptor activation
GABA receptor activation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
46.8
birth weight
1
1
1
44.2
body height
1
1
1
42.3
waist circumference
2
2
2
36.9
tooth eruption
1
1
1
34.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
46.8
birth weight
1
44.2
body height
1
42.3
waist circumference
2
36.9
tooth eruption
1
34.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 16
VGNC:9344
468311
Macaque
potassium voltage-gated channel subfamily J member 16
694188
Mouse
MGI:1314842
16517
Rat
RGD:61824
29719
Dog
potassium voltage-gated channel subfamily J member 16
VGNC:42262
611045
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 16
Macaque
potassium voltage-gated channel subfamily J member 16
Mouse
Rat
Dog
potassium voltage-gated channel subfamily J member 16
Publication Statistics
PubMed Score 51.01
PubMed score by year
PubTator Score 23.73
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title