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Tchem
FANCF
Fanconi anemia group F protein

Protein Summary
Description
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity). The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327470
  • ENSP00000330875
  • ENSG00000183161

Symbol
  • FAF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
histone modification site profile
0.87
cell type or tissue
0.83
gene perturbation
0.71
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.9   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.9   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (82)
RMI1
Tbio
Novelty:  0.01222442
Score:  0.999
Data Source:  STRINGDB
HES1
Tbio
Family:  TF
Novelty:  0.00974115
Score:  0.999
Data Source:  STRINGDB
FANCC
Tbio
Novelty:  0.00546581
Score:  0.999
Data Source:  STRINGDB
CENPX
Tbio
Novelty:  0.08344454
Score:  0.999
Data Source:  STRINGDB
FANCM
Tbio
Novelty:  0.01122278
Score:  0.999
Data Source:  STRINGDB
FAAP100
Tdark
Novelty:  0.1698504
Score:  0.999
Data Source:  STRINGDB
FANCG
Tbio
Novelty:  0.00908902
Score:  0.999
Data Source:  STRINGDB
FANCL
Tbio
Family:  Enzyme
Novelty:  0.00274467
Score:  0.999
Data Source:  STRINGDB
CENPS
Tbio
Novelty:  0.0085893
Score:  0.999
Data Source:  STRINGDB
FAAP20
Tbio
Novelty:  0.15112645
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Name
Explore in Pharos
Explore in Source
DNA Repair
Fanconi Anemia Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group F
749534
Macaque
Fanconi anemia complementation group F
704048
Mouse
MGI:3689889
100040608
Rat
RGD:1561456
499155
Dog
FA complementation group F
VGNC:40721
102152851
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fanconi anemia complementation group F
Macaque
Fanconi anemia complementation group F
Mouse
Rat
Dog
FA complementation group F
Publication Statistics
PubMed Score 52.90
PubMed score by year
PubTator Score 52.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title