FANCF
Fanconi anemia group F protein
Protein Summary
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity). The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008]
- ENST00000327470
- ENSP00000330875
- ENSG00000183161
- FAF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.88 | ||
histone modification site profile | 0.87 | ||
cell type or tissue | 0.83 | ||
gene perturbation | 0.71 | ||
kinase perturbation | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.9 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 173 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 52.9 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 173 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (1)
Protein-Protein Interactions (82)
Nearest Tclin Targets
Pathways (5)
Reactome (2)
KEGG (1)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | DNA Repair | ||||
Reactome | Fanconi Anemia Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
DNA Repair | ||||
Fanconi Anemia Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Components (2)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (0)
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IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Fanconi anemia complementation group F | 749534 | ||||||
Macaque | Fanconi anemia complementation group F | 704048 | ||||||
Mouse | MGI:3689889 | 100040608 | ||||||
Rat | RGD:1561456 | 499155 | ||||||
Dog | FA complementation group F | VGNC:40721 | 102152851 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Fanconi anemia complementation group F | |||||
Macaque | Fanconi anemia complementation group F | |||||
Mouse | ||||||
Rat | ||||||
Dog | FA complementation group F | |||||
Publication Statistics
PubMed Score 52.90
PubMed score by year
PubTator Score 52.36
PubTator score by year
Related Publications
Text Mined References (40)
GeneRif Annotations (19)
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