Tbio DCP1A mRNA-decapping enzyme 1A

Protein Summary

Description

Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• Q9NPI6
• B4DHN9
• U3KQM8

Gene Name

• DCP1A

Ensembl ID

• ENST00000294241
• ENSP00000476046
• ENSG00000272886
• ENST00000610213
• ENSP00000476386

Symbol

• SMIF
• SMIF
• SMAD4IP1
• HSA275986
• Nbla00360

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
transcription factor binding site profile	0.92
virus perturbation	0.9
transcription factor perturbation	0.74
histone modification site profile	0.69

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Mrna-decapping Enzyme 1a

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Mrna-decapping Enzyme 1a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.88   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 338   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.88   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0