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Tbio
DCP1A
mRNA-decapping enzyme 1A

Protein Summary
Description
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294241
  • ENSP00000476046
  • ENSG00000272886
  • ENST00000610213
  • ENSP00000476386

Symbol
  • SMIF
  • SMIF
  • SMAD4IP1
  • HSA275986
  • Nbla00360
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor binding site profile
0.92
virus perturbation
0.9
transcription factor perturbation
0.74
histone modification site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.71   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.71   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erosive tooth wear measurement
1
1
0
4.9
18.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
erosive tooth wear measurement
0
4.9
18.1
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA (R-HSA-450385)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Reactome
Nonsense-Mediated Decay (NMD)
Name
Explore in Pharos
Explore in Source
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Deadenylation-dependent mRNA decay
Metabolism of RNA
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Nonsense-Mediated Decay (NMD)
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (255)
1 – 10 of 255
DDX6
Tbio
Family: Enzyme
Novelty: 0.01032357
p_int: 0.99917662
p_ni: 0.00082338
Score: 0.999
Data Source: BioPlex,STRINGDB
PNLIPRP2
Tbio
Family: Enzyme
p_int: 0.990684307
p_ni: 0.009315693
Data Source: BioPlex
DCP2
Tbio
Family: Enzyme
Novelty: 0.00661786
p_int: 0.98885029
p_ni: 0.01114971
Score: 0.999
Data Source: BioPlex,STRINGDB
EDC3
Tbio
Novelty: 0.02077346
p_int: 0.984475769
p_ni: 0.015524231
Score: 0.999
Data Source: BioPlex,STRINGDB
BAG4
Tbio
Novelty: 0.02660607
p_int: 0.982357097
p_ni: 0.017642903
Score: 0.752
Data Source: BioPlex,STRINGDB
GADD45GIP1
Tbio
Novelty: 0.03765684
p_int: 0.9780306
p_ni: 0.0219694
Data Source: BioPlex
PIM1
Tchem
Family: Kinase
Novelty: 0.0049837
p_int: 0.970527453
p_ni: 0.029472547
Score: 0.869
Data Source: BioPlex,STRINGDB
USP4
Tbio
Family: Enzyme
Novelty: 0.01101075
p_int: 0.896204812
p_ni: 0.103795188
Data Source: BioPlex
CCDC59
Tbio
Novelty: 0.05894885
p_int: 0.84038762
p_ni: 0.15961238
Score: 0.263
Data Source: BioPlex,STRINGDB
EDC4
Tbio
Novelty: 0.00365253
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.71

PubMed score by year
PubTator Score  29.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer