You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
BRD7
Bromodomain-containing protein 7

Protein Summary
Description
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. This gene encodes a protein which is a member of the bromodo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394688
  • ENSP00000378180
  • ENSG00000166164
  • ENST00000394689
  • ENSP00000378181

Symbol
  • BP75
  • CELTIX1
  • BP75
  • NAG4
  • CELTIX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
biological process
0.85
interacting protein
0.8
molecular function
0.67
hub protein
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.45   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.45   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (116)
SMARCB1
Tbio
Novelty:  0.00116387
p_int:  0.999999993
p_ni:  8e-9
Score:  0.889
Data Source:  BioPlex,STRINGDB
SMARCC2
Tbio
Family:  TF; Epigenetic
Novelty:  0.02625321
p_int:  0.999999984
p_ni:  1.6e-8
Score:  0.983
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.999999973
p_ni:  2.7e-8
Score:  0.861
Data Source:  BioPlex,STRINGDB
SMARCD1
Tbio
Novelty:  0.03176642
p_int:  0.999999697
p_ni:  3.03e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
DPF3
Tbio
Family:  Epigenetic
Novelty:  0.069151
p_int:  0.99999956
p_ni:  4.4e-7
Score:  0.988
Data Source:  BioPlex,STRINGDB
SMARCE1
Tbio
Family:  TF
Novelty:  0.01748089
p_int:  0.999997064
p_ni:  0.000002936
Score:  0.995
Data Source:  BioPlex,STRINGDB
BCL7A
Tbio
Novelty:  0.07026394
p_int:  0.999987258
p_ni:  0.000012742
Score:  0.81
Data Source:  BioPlex,STRINGDB
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.999417559
p_ni:  0.000582336
p_wrong:  1.06e-7
Score:  0.577
Data Source:  BioPlex,STRINGDB
RPL37
Tbio
Novelty:  0.03935854
p_int:  0.977897894
p_ni:  0.022097858
p_wrong:  0.000004248
Data Source:  BioPlex
ARID2
Tbio
Family:  TF
Novelty:  0.01767212
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Acetylation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Acetylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
67.3
autoimmune thyroid disease
1
1
0
1.5
62.1
1
1
0
2.2
62.1
eosinophil count
2
1
2
60.5
Thyroid preparation use measurement
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
67.3
autoimmune thyroid disease
0
1.5
62.1
0
2.2
62.1
eosinophil count
2
60.5
Thyroid preparation use measurement
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bromodomain containing 7
VGNC:5681
100614563
Macaque
bromodomain containing 7
694850
Mouse
MGI:1349766
26992
Rat
RGD:1309891
361374
Dog
bromodomain containing 7
VGNC:38521
478130
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bromodomain containing 7
Macaque
bromodomain containing 7
Mouse
Rat
Dog
bromodomain containing 7
Publication Statistics
PubMed Score 75.45
PubMed score by year
PubTator Score 41.12
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title